Article
Chemistry, Physical
Haonan Li, Rong Chen, Xun Zhu, Dingding Ye, Yang Yang, Wei Li, Dongliang Li, Qiang Liao
Summary: A novel and facile light strategy is presented to manipulate macroscopic crystal morphology during droplet evaporative crystallization. Different crystal skeletons, such as spherical coronal shell, alms bowl-like skeleton, and cylindrical shell-like skeleton with controllable cavity, can be achieved on photosensitive hydrophobic substrates. The study also shows that the addition of certain compounds can lead to the formation of closed crystal skeletons with the solution wrapped inside.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Samaneh Zare Harofte, Madjid Soltani, Saeed Siavashy, Kaamran Raahemifar
Summary: Nowadays, artificial intelligence creates numerous opportunities in the life sciences. Integrating AI with microfluidics can significantly impact various fields of biotechnology.
Article
Chemistry, Physical
Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ovidiu Oprea, Adrian Ionut Nicoara, Chih-Hui Yang, Keng-Shiang Huang, Ecaterina Andronescu
Summary: The study introduced a new method for the synthesis of magnetite nanoparticles using a microfluidic lab-on-chip device to achieve controlled properties. It investigated the influence of iron precursor solution concentration and flow on the final properties of the nanomaterials, ultimately achieving uniformity and stability in the synthesized nanoparticles.
Review
Chemistry, Analytical
Ruth Shinar, Joseph Shinar
Summary: Organic electronics (OE) technology has matured in displays and is advancing in solid-state lighting applications. It also shows great potential in (bio)chemical sensing, imaging, in vitro cell monitoring, and other biomedical diagnostics. OE devices, such as organic LEDs, organic and hybrid perovskite-based photodetectors, and organic thin-film transistors, are utilized in these applications. The integration of compact and sensitive OE devices with microfluidic channels and lab-on-a-chip (LOC) structures is very promising.
Article
Chemistry, Analytical
Daphika S. Dkhar, Rohini Kumari, Shweta J. Malode, Nagaraj P. Shetti, Pranjal Chandra
Summary: Lab-on-a-chip (LOC) biosensors have attracted research interest for their potential in personal healthcare and disease diagnostics. This review discusses various fabrication methods and techniques for designing LOC sensing devices, as well as the types of transduction systems that play a crucial role in sensing. The detection of analytes, including small molecules, macromolecules, and cells, is comprehensively reviewed with illustrations and tables.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Article
Chemistry, Multidisciplinary
Rosalia Moreddu, Vahid Nasrollahi, Panagiotis Kassanos, Stefan Dimov, Daniele Vigolo, Ali K. Yetisen
Summary: In this article, femtosecond laser writing is used to engrave microfluidic networks into commercial contact lenses, achieving rapid and precise processing. The ablation process and tear flow within microfluidic structures are evaluated experimentally and computationally. Functional microfluidic components such as flow valves, resistors, and two applications, a tear volume sensor and a tear uric acid sensor, are introduced, providing painless alternatives with reduced contamination risks.
Article
Environmental Sciences
Matt Mowlem, Alexander Beaton, Robin Pascal, Allison Schaap, Socratis Loucaides, Sam Monk, Andrew Morris, Christopher L. Cardwell, Sara E. Fowell, Matthew D. Patey, Patricia Lopez-Garcia
Summary: A new product line utilizing in situ lab on chip technology has been introduced for high accuracy measurements of water chemistry parameters, even in deep sea environments. Commercially available sensors include Nitrate, Nitrite, Phosphate, Silicate, Iron, and pH sensors. The technology is adaptable for a wide range of environmental measurements, particularly for chemical and biological parameters that require reagents.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Chemistry, Analytical
Pornchanok Punnoy, Tatiya Siripongpreda, Trairak Pisitkun, Nadnudda Rodthongkum, Pranut Potiyaraj
Summary: A novel lab-on-paper screening method using gold nanoparticles and laser desorption ionization-mass spectrometry (LDI-MS) was developed for rapid diagnosis of the SARS-CoV-2 Omicron BA.2 variant. The method allows for sensitive detection of SARS-CoV-2 antigen and can be used for quantitation of the antigen in saliva without the need for sample preparation. This platform could potentially be used for non-invasive diagnosis of the Omicron BA.2 variant.
Article
Biochemistry & Molecular Biology
Emanuele Piccinno, Anna Grazia Monteduro, Francesco Dituri, Silvia Rizzato, Gianluigi Giannelli, Giuseppe Maruccio
Summary: The study validated a miniaturized on-chip platform for real-time, non-destructive cell proliferation assays and drug screening, comparing its effectiveness with the traditional 96-well plate assay. Results showed the new platform's efficacy comparable to the standard method, with advantages in reagent consumption, operator time, and costs, potentially accelerating drug development processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Dorina T. Papanastasiou, Abderrahime Sekkat, Viet Huong Nguyen, Carmen Jimenez, David Munoz-Rojas, Franz Bruckert, Daniel Bellet
Summary: This paper introduces a transparent heater based on silver nanowire networks, protected with a transparent zinc oxide film, for temperature control in biological experiments under transparent microscopic observation. The experimental results demonstrate that the nanocomposites allow rapid and reproducible heating under low applied voltage, and achieve selective heating in different zones of microchannels or adjacent microchannels at different temperatures.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Agnieszka Krakos (Podwin), Patrycja Sniadek, Marta Jurga, Marcin Bialas, Agata Kaczmarek-Pienczewska, Krzysztof Matkowski, Rafal Walczak, Jan Dziuban
Summary: This paper presents a lab-on-chip system designed for cultivating fungi in both Earth's gravity and simulated microgravity, with potential applications in nanosatellite missions. The study demonstrates the successful growth of Fusarium culmorum fungi using the lab-on-chip system, both on the ground and in simulated microgravity conditions. Interestingly, the results show that microgravity significantly stimulates the growth of fungi compared to normal gravity. These findings provide valuable insights into the cultivation of microscopic fungi in lab-on-chip devices and their behavior in microgravity conditions.
APPLIED SCIENCES-BASEL
(2022)
Article
Biophysics
Guanlin Zhou, Chao Wang, Chengwei Wu, Wei Zhang
Summary: The cell elastic modulus is widely used as a mechanics-based marker to analyze the biological effects of substrates on cells. However, the traditional Hertz model used to extract the apparent elastic modulus can cause errors due to violations of the small deformation assumption, infinite half-space assumption, and inability to account for substrate deformation. In this study, an active learning model is proposed to effectively extract the cell elastic modulus and reduce extraction errors. Numerical calculations and indentation experiments confirm the accuracy and efficiency of the established model.
BIOPHYSICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Daniel A. Ferreira, Mario Rothbauer, Joao P. Conde, Peter Ertl, Carla Oliveira, Pedro L. Granja
Summary: A streamlined approach for fabricating organ-on-a-chip devices using an adaptation of xurography is proposed, allowing rapid and low-cost generation of multilayered, membrane-integrated biochips suitable for organ-on-a-chip applications without cytotoxic effects on cells.
Review
Biotechnology & Applied Microbiology
Hongyong Zhang, Guoguang Rong, Sumin Bian, Mohamad Sawan
Summary: With the increasing population, neurological disorders have become a growing concern. However, there is still a lack of effective therapies. Understanding the neuronal network (NoN) in the human brain is essential for understanding the pathology of neurological diseases. Recent advances in nanomaterials and micro-/nano-microfabrication have opened up new possibilities for ex vivo NoN studies. This review summarizes the latest advances in lab-on-chip microsystems for ex vivo NoN studies, focusing on advanced materials, techniques, and models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Mina Fatahian-Nezhad, Robabeh Alizadeh, Sanam Sadeghi Mohammadi, Mohammad Tohidlou, Hossein Naderi-Manesh, Vahid Amani
Summary: The Pd(II) complexes were synthesized and characterized, demonstrating binding to DNA and anti-tumor properties. The 5,6-dmphen ligand showed significant cytotoxicity and played a crucial role in the cytotoxic activity of the complexes.
INORGANICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Jalil Parchekani, Abdollah Allahverdi, Majid Taghdir, Hossein Naderi-Manesh
Summary: Simulated liposome models play a crucial role in molecular biological science and cellular biology, providing insights into cell membrane mechanisms, biological cell interactions, and drug delivery systems. These models are beneficial for understanding membrane behavior, drug penetration, vesicle formation, and membrane protein functions. The use of molecular dynamics simulations allows for the investigation of lipid membrane formation and the design of optimal liposomes as potential drug carriers.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Hadi Hashemzadeh, Ali Hamad Abd Kelkawi, Abdollah Allahverdi, Mario Rothbauer, Peter Ertl, Hossein Naderi-Manesh
Summary: The inadequacy of animal models has led to the development of improved in vitro models, such as 3D multicellular spheroids, for drug efficacy assessments. While these models provide physiological relevance and meet high-throughput and low-cost requirements for drug discovery, their application in nanotoxicity testing is still in its early stages due to limited penetration and uptake rates. Comparative studies between 2D monolayer cultures and 3D spheroids revealed distinct cellular responses to gold nanowires (AuNWs) treatment, emphasizing the need for more physiologically relevant tissue models for investigating nanomaterial-biology interactions.
Article
Chemistry, Analytical
Zoran Djinovic, Milos Tomic, Agnes Kocsis
Summary: This paper presents a method that combines micromachined optofluidic platforms with fiberoptic sensing configuration for simultaneous measurement of the refractive index of liquids and autocalibration. The method is based on low-coherence interferometry and an algorithm is used to calculate the refractive index from raw interference signals.
Article
Chemistry, Multidisciplinary
Rashin Mohammadi, Mohammad Asghari, Monika Colombo, Zahra Vaezi, Daniel A. Richards, Stavros Stavrakis, Hossein Naderi-Manesh, Andrew DeMello
Summary: This study presents the design and optimization of a microfluidic device that can automatically isolate circulating tumor cells (CTCs) from whole blood, which is challenging due to the low concentration of CTCs and their mixture with other blood components. The device achieves separation through passive viscoelastic separation and subsequent active magnetophoretic separation. Magnetic biosilica frustules are used for tagging and magnetic isolation of CTCs. The platform demonstrates high recovery and purity of CTCs.
Article
Multidisciplinary Sciences
Mohammad Hasan Darvishi, Abdollah Allahverdi, Hadi Hashemzadeh, Hamid Reza Javadi
Summary: SiRNA is a promising drug molecule for treating various diseases, but its efficient delivery to cells remains a challenge. This study investigated the interaction of siRNA with lipid carriers and the role of ion concentration and lipid conjugation. The findings demonstrated that divalent cations can enhance siRNA attachment to the lipid bilayer surface, and calcium ions play a crucial role in the interaction between cholesterol-modified siRNA and the membrane. These insights contribute to the development of liposome carriers for siRNA delivery and hold potential for the treatment of diseases, including the ongoing coronavirus pandemic.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Zhila Ziaei-Rad, Mohammad Pazouki, Jamshid Fooladi, Mehrdad Azin, Sathyanarayana N. Gummadi, Abdollah Allahverdi
Summary: The cost-effective pretreatment of wheat straw using low-cost ionic liquid [TEA][HSO4] coupled with ultrasound irradiation was studied. The results showed that wheat straw pretreated at 130 degrees C for 15 and 30 min had high delignification rates of 67.8% and 74.9%, respectively, and hemicellulose removal rates of 47.0% and 52.2%. Enzymatic saccharification of the pretreated samples resulted in high saccharification yields of 67.7% and 79.8% and ethanol generation rates of 38.9 g/L and 42.0 g/L. This study demonstrated a promising and cost-effective pretreatment technology for bioethanol production.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Shahin Ramazi, Mani Salimian, Abdollah Allahverdi, Shahla Kianamiri, Parviz Abdolmaleki
Summary: Breast cancer is a leading cause of cancer deaths in women worldwide. Magnetic fields have been found to have anti-tumor effects and can remotely affect cellular metabolism as a non-invasive therapy. Combining chemotherapy and magnetotherapy may be an effective treatment for breast cancer.
SCIENTIFIC REPORTS
(2023)
Review
Genetics & Heredity
Zahra Sahafnejad, Shahin Ramazi, Abdollah Allahverdi
Summary: Epigenetics is a significant field in biology that investigates changes in gene expression patterns not attributed to DNA sequence changes. Epigenetic marks, such as histone modifications, non-coding RNAs, and DNA methylation, play crucial roles in gene regulation. Aberrant epigenetic marks have been found to be associated with various diseases.
Article
Nanoscience & Nanotechnology
Mojtaba Shamsipur, Elaheh Babaee, Mohammad-Bagher Gholivand, Fatemeh Molaabasi, Farimah Mousavi, Ali Barati, Behnam Hajipour Verdom, Behnaz Shojaedin-Givi, Hossein Naderi-Manesh
Summary: In this study, a new fluorescence probe based on insulin-capped gold nanoclusters (Ins/Au-NCs) was developed for selective detection of Cu2+ ions and glutathione (GSH). The probe showed high sensitivity and stability. Cu2+ ions caused fluorescence quenching of Ins/Au-NCs, which could be recovered in the presence of GSH. The probe had low detection limits and broad linear ranges for Cu2+ ions and GSH. It also showed promising application in detecting low levels of Cu2+ ions and GSH in water and human serum samples.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Seyed Mohammad Reza Mortazavi, Zahra Vaezi, Reza Mahdavian, Mohsen Barzegar, Hossein Naderi-Manesh
Summary: In order to treat inflammatory bowel disease (IBD), researchers are developing a local drug delivery system. In this study, a novel composite cerasome was prepared by mixing organosilane-based oleic acid with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. The results show that this novel cerasome has great potential as a non-ulcerogenic agent in IBD therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Hadi Hashemzadeh, Zahra Khadivi-Khanghah, Abdollah Allahverdi, Mohammad Mehdi Hadipour, Esmaiel Saievar-Iranizad, Hossein Naderi-Manesh
Summary: Conventional serological methods for detecting brucellosis are time-consuming and expensive, while new approaches are more sensitive. To improve detection, electrochemical nanostructured platforms, such as the graphene oxide nanowall-gold nanoflower platform, offer excellent electroactivity and antifouling properties, making them more sensitive than bare electrodes.
Review
Mathematical & Computational Biology
Shahin Ramazi, Neda Mohammadi, Abdollah Allahverdi, Elham Khalili, Parviz Abdolmaleki
Summary: Antimicrobial Peptides (AMPs) are natural peptides that play a crucial role in the immune system and have the potential to be used as alternative infection therapeutics. They have short lengths and are effective against microbes, with low toxicity in mammals. Computational methods have advanced the study of AMPs and provided valuable resources for designing new models for AMP prediction. However, more research is needed to accurately evaluate and analyze these computational methods.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2022)