The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

(2019) Shyam S. Bansal et al.   CIRCULATION

Physical Exercise Induces Immunoregulation of TREG, M2, and pDCs in a Lung Allergic Inflammation Model

(2019) Paula Fernandes et al.   Frontiers in Immunology

A Switch in TGF-β Signaling Explains Contradictory Findings in Pulmonary Arterial Hypertension

(2018) Laszlo Farkas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

(2018) Bruce R. Blazar et al.   BLOOD

Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary HypertensionNovelty and Significance

(2018) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice

(2018) Guilin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCL5 deficiency rescues pulmonary vascular dysfunction, and reverses pulmonary hypertension via caveolin-1-dependent BMPR2 activation

(2018) Xiaowei Nie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension

(2018) Cheng Li et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel

(2018) Pei-Pei Shao et al.   Frontiers in Physiology

An upregulation of CD8 + CD25 + Foxp3 + T cells with suppressive function through interleukin 2 pathway in pulmonary arterial hypertension

(2017) Rong Zhu et al.   EXPERIMENTAL CELL RESEARCH

Cytokine mediators of chronic graft-versus-host disease

(2017) Kelli P.A. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction

(2017) Vimal Ramjee et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension

(2017) Alice Bourgeois et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

(2017) Kai Yang et al.   NATURE

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1

(2017) Nanhai He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

(2017) Gavin Whitehouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

(2017) A.A. Roger Thompson et al.   TRENDS IN MOLECULAR MEDICINE

Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways

(2017) Shian Huang et al.   Biomed Research International

Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium–Sensing Receptor

(2017) Rui Xiao et al.   Journal of the American Heart Association

Chronic use of PAH-specific therapy in World Health Organization Group III Pulmonary Hypertension: a systematic review and meta-analysis

(2017) Kurt W. Prins et al.   Pulmonary Circulation

Exogenous interleukin 37 ameliorates atherosclerosis via inducing the Treg response in ApoE-deficient mice

(2017) Qingwei Ji et al.   Scientific Reports

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension

(2016) Alice Huertas et al.   CHEST

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target SlugCLINICAL PERSPECTIVE

(2016) Rachel K. Hopper et al.   CIRCULATION

Pulmonary veno-occlusive disease

(2016) David Montani et al.   EUROPEAN RESPIRATORY JOURNAL

The right ventricle and pulmonary hypertension

(2016) Mariëlle C. van de Veerdonk et al.   HEART FAILURE REVIEWS

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension

(2015) Isabel Diebold et al.   Cell Metabolism

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

(2015) Dandan Wang et al.   Cellular & Molecular Immunology

New Molecular Targets of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

(2015) Christophe Guignabert et al.   CHEST

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

Leukotriene B4Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension

(2015) Jin Qian et al.   HYPERTENSION

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Treg depletion attenuates irradiation-induced pulmonary fibrosis by reducing fibrocyte accumulation, inducing Th17 response, and shifting IFN-γ, IL-12/IL-4, IL-5 balance

(2015) Shanshan Xiong et al.   IMMUNOBIOLOGY

Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension

(2015) Frédéric Perros et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family

(2015) Erna Sziksz et al.   MEDIATORS OF INFLAMMATION

Regulatory T cells in cardiovascular diseases

(2015) Xiao Meng et al.   Nature Reviews Cardiology

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension

(2014) Nicolas Ricard et al.   CIRCULATION

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells

(2014) K. M. Hew et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in idiopathic pulmonary fibrosis patients

(2014) Domenico Galati et al.   CYTOKINE

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

The importance of regulatory T-cell heterogeneity in maintaining self-tolerance

(2014) Xiaomei Yuan et al.   IMMUNOLOGICAL REVIEWS

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases

(2014) Saren Gaowa et al.   MEDIATORS OF INFLAMMATION

Regulatory T cells protect against hypoxia-induced pulmonary arterial hypertension in mice

(2014) YANBIAO CHU et al.   Molecular Medicine Reports

Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

(2014) Yuka Maeda et al.   SCIENCE

CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung

(2014) Xueyan Peng et al.   Frontiers in Pharmacology

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Fate Mapping in Mice With Pulmonary Hypertension

(2013) Lina Qiao et al.   CIRCULATION

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08

(2013) Paula Tabares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adoptive Transfer of Regulatory T Cells Protects against Coxsackievirus B3-Induced Cardiac Fibrosis

(2013) Yanxia Cao et al.   PLoS One

Telmisartan attenuates monocrotaline-induced pulmonary artery endothelial dysfunction through a PPAR gamma-dependent PI3K/Akt/eNOS pathway

(2013) He Li et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing

(2012) Catalin F. Baicu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pharmacologic Agents Elevating cAMP Prevent Arginase II Expression and Proliferation of Pulmonary Artery Smooth Muscle Cells

(2012) Bernadette Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulatory T Cells Reduce Acute Lung Injury Fibroproliferation by Decreasing Fibrocyte Recruitment

(2012) Brian T. Garibaldi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension

(2012) Alice Huertas et al.   EUROPEAN RESPIRATORY JOURNAL

Differential role of regulatory T cells in early and late stages of pulmonary fibrosis

(2012) Daniel Boveda-Ruiz et al.   IMMUNOBIOLOGY

Regulatory T Cells and Pulmonary Hypertension

(2012) Rasa Tamosiuniene et al.   TRENDS IN CARDIOVASCULAR MEDICINE

New Models of Pulmonary Hypertension Based on VEGF Receptor Blockade-Induced Endothelial Cell Apoptosis

(2012) Mark R. Nicolls et al.   Pulmonary Circulation

Targeting the Adventitial Microenvironment in Pulmonary Hypertension: A Potential Approach to Therapy that Considers Epigenetic Change

(2012) Kurt R. Stenmark et al.   Pulmonary Circulation

Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis

(2011) Sandra Lo Re et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension

(2011) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

(2011) M. Li et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

(2010) Shigeru Saito et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension

(2009) E.D. Austin et al.   RESPIRATORY MEDICINE

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE