The Phospholipase Cγ2Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment

(2016) Elisa ten Hacken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

(2016) Maicol Mancini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

(2016) Jan A. Burger et al.   Nature Communications

Hypermorphic mutation of phospholipase C,  2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

(2015) T.-M. Liu et al.   BLOOD

FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia

(2015) R. A. de Claro et al.   CLINICAL CANCER RESEARCH

Advances in first-line treatment of chronic lymphocytic leukemia: current recommendations on management and first-line treatment by the German CLL Study Group (GCLLSG)

(2015) Paula Cramer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Rac-mediated Stimulation of Phospholipase Cγ2Amplifies B Cell Receptor-induced Calcium Signaling

(2015) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aptamers: new arrows to target dendritic cells

(2015) A. Ganji et al.   JOURNAL OF DRUG TARGETING

Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

(2015) Wyndham H Wilson et al.   NATURE MEDICINE

Ibrutinib for the treatment of Waldenström macroglobulinemia

(2015) Rajshekhar Chakraborty et al.   Expert Review of Hematology

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

(2015) Kami J. Maddocks et al.   JAMA Oncology

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

(2014) Jennifer A. Woyach et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

(2014) N. L. Komarova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss

(2013) Masahiro Shinohara et al.   BONE

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

(2012) Qing Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mammalian Phospholipase C

(2012) Ganesh Kadamur et al.   Annual Review of Physiology

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

(2012) Marcus Dühren-von Minden et al.   NATURE

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

(2012) Tom D. Bunney et al.   STRUCTURE

B-cell receptor signaling in chronic lymphocytic leukemia

(2011) F. K. Stevenson et al.   BLOOD

AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments

(2011) B. Stamatopoulos et al.   HAEMATOLOGICA

Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase C 2

(2011) K. L. Everett et al.   MOLECULAR AND CELLULAR BIOLOGY

Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2

(2010) Aiko-Konno Shirakawa et al.   Cellular & Molecular Immunology

Innate and Adaptive Receptors Interact to Balance Humoral Immunity

(2010) Thomas F. Tedder   JOURNAL OF IMMUNOLOGY

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the large-conductance background K+ channel in mouse B cells as TREK-2

(2009) Haifeng Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autoinhibition and adapter function of Syk

(2009) Yogesh Kulathu et al.   IMMUNOLOGICAL REVIEWS

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

(2009) Katy L. Everett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NF- B subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target

(2008) S. Hewamana et al.   BLOOD

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

(2008) M. Muzio et al.   BLOOD

Activation of the Small GTPase Rac2 via the B Cell Receptor Regulates B Cell Adhesion and Immunological-Synapse Formation

(2008) Eloisa Arana et al.   IMMUNITY

Rac Regulates Its Effector Phospholipase Cγ2through Interaction with a Split Pleckstrin Homology Domain

(2008) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

(2008) Michele Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation

(2008) P. Ghia et al.   JOURNAL OF INTERNAL MEDICINE

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

(2008) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY