CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4

Visualization of clustered protocadherin neuronal self-recognition complexes

(2019) Julia Brasch et al.   NATURE

Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance

(2018) Samantha Ing-Esteves et al.   JOURNAL OF NEUROSCIENCE

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

(2018) Felicity Allen et al.   NATURE BIOTECHNOLOGY

DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members

(2018) Andrew M. Garrett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain

(2017) Yan Jiang et al.   NATURE GENETICS

CRISPR-mediated isolation of specific megabase segments of genomic DNA

(2017) Pamela E. Bennett-Baker et al.   NUCLEIC ACIDS RESEARCH

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly

(2017) George Mountoufaris et al.   SCIENCE

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice

(2017) Weisheng V. Chen et al.   SCIENCE

Structural origins of clustered protocadherin-mediated neuronal barcoding

(2017) Rotem Rubinstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

γ-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis

(2017) Michael J. Molumby et al.   Cell Reports

Clustered Protocadherins Are Required for Building Functional Neural Circuits

(2017) Sonoko Hasegawa et al.   Frontiers in Molecular Neuroscience

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins

(2016) Kerry Marie Goodman et al.   NEURON

The γ-Protocadherin-C3 isoform inhibits canonical Wnt signalling by binding to and stabilizing Axin1 at the membrane

(2016) Kar Men Mah et al.   Scientific Reports

Homophilic Protocadherin Cell-Cell Interactions Promote Dendrite Complexity

(2016) Michael J. Molumby et al.   Cell Reports

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

(2016) Joffrey Mianné et al.   Genome Medicine

γ-Protocadherin structural diversity and functional implications

(2016) Kerry Marie Goodman et al.   eLife

Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse

(2016) Andrew M. Garrett et al.   Frontiers in Molecular Neuroscience

Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting

(2016) Sonoko Hasegawa et al.   Frontiers in Molecular Neuroscience

Exome sequencing in the knockin mice generated using the CRISPR/Cas system

(2016) Kazuo Nakajima et al.   Scientific Reports

Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions

(2015) Rotem Rubinstein et al.   CELL

Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization

(2015) Austin B. Keeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice

(2015) Reiko Meguro et al.   JOURNAL OF NEUROCHEMISTRY

Off-target mutations are rare in Cas9-modified mice

(2015) Vivek Iyer et al.   NATURE METHODS

Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes

(2015) Ryuichi Ono et al.   Scientific Reports

Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function

(2015) Dimitar Kostadinov et al.   eLife

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Single-Cell Identity Generated by Combinatorial Homophilic Interactions between α, β, and γ Protocadherins

(2014) Chan Aye Thu et al.   CELL

Microhomology-based choice of Cas9 nuclease target sites

(2014) Sangsu Bae et al.   NATURE METHODS

Developmental Epigenetic Modification Regulates Stochastic Expression of Clustered Protocadherin Genes, Generating Single Neuron Diversity

(2014) Shunsuke Toyoda et al.   NEURON

BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers

(2014) Ryan P. Abo et al.   NUCLEIC ACIDS RESEARCH

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system

(2012) Julie L. Lefebvre et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

γ-Protocadherins Control Cortical Dendrite Arborization by Regulating the Activity of a FAK/PKC/MARCKS Signaling Pathway

(2012) Andrew M. Garrett et al.   NEURON

Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster

(2012) Weisheng V. Chen et al.   NEURON

Identification of CTCF as a master regulator of the clustered protocadherin genes

(2012) Michal Golan-Mashiach et al.   NUCLEIC ACIDS RESEARCH

Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-  gene expression

(2012) K. Monahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase

(2012) Lun Suo et al.   Journal of Molecular Cell Biology

CTCF Is Required for Neural Development and Stochastic Expression of Clustered Pcdh Genes in Neurons

(2012) Teruyoshi Hirayama et al.   Cell Reports

Identification of the Cluster Control Region for the Protocadherin-β Genes Located beyond the Protocadherin-γ Cluster

(2011) Shinnichi Yokota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory elements required for the activation and repression of the protocadherin-  gene cluster

(2011) P. Kehayova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the γ-Protocadherins

(2011) Tuhina Prasad et al.   Frontiers in Molecular Neuroscience

Chemoaffinity Revisited: Dscams, Protocadherins, and Neural Circuit Assembly

(2010) S. Lawrence Zipursky et al.   CELL

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Combinatorial homophilic interaction between  -protocadherin multimers greatly expands the molecular diversity of cell adhesion

(2010) D. Schreiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice

(2009) Hong Su et al.   DEVELOPMENTAL BIOLOGY

Total Expression and Dual Gene-regulatory Mechanisms Maintained in Deletions and Duplications of thePcdhaCluster

(2009) Yukiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of CNS Synapse Development by  -Protocadherin-Mediated Astrocyte-Neuron Contact

(2009) A. M. Garrett et al.   JOURNAL OF NEUROSCIENCE

Protocadherin-  Family Is Required for Serotonergic Projections to Appropriately Innervate Target Brain Areas

(2009) S. Katori et al.   JOURNAL OF NEUROSCIENCE

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms

(2009) Daisuke Hattori et al.   NATURE

DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina

(2009) Peter G. Fuerst et al.   NEURON

Dscam-Mediated Cell Recognition Regulates Neural Circuit Formation

(2008) Daisuke Hattori et al.   Annual Review of Cell and Developmental Biology

A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-  gene cluster

(2008) T. Prasad et al.   DEVELOPMENT

 -Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina

(2008) J. L. Lefebvre et al.   DEVELOPMENT

Inhibition of protocadherin-α function results in neuronal death in the developing zebrafish

(2008) Michelle R. Emond et al.   DEVELOPMENTAL BIOLOGY

Gamma-protocadherin homophilic interaction and intracellular trafficking is controlled by the cytoplasmic domain in neurons

(2008) Monica Fernández-Monreal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurite arborization and mosaic spacing in the mouse retina require DSCAM

(2008) Peter G. Fuerst et al.   NATURE