Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns

(2018) Laura Magill Sack et al.   CELL

Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability

(2018) Franck Raynaud et al.   PLoS Genetics

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

(2017) Yi Kan Wang et al.   NATURE GENETICS

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

(2017) Joe Ryan Delaney et al.   Nature Communications

Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy

(2017) B Xu et al.   Oncogenesis

Prevalence of deleterious germline variants in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1)

(2017) Philipp Harter et al.   PLoS One

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

(2016) Graeme Hewitt et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

(2016) Pei-Chi Wei et al.   CELL

CometQ: An automated tool for the detection and quantification of DNA damage using comet assay image analysis

(2016) Sreelatha Ganapathy et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Characterization of ovarian cancer cell lines as in vivo models for preclinical studies

(2016) Lidia Hernandez et al.   GYNECOLOGIC ONCOLOGY

Autophagy in adhesion and migration

(2016) Candia M. Kenific et al.   JOURNAL OF CELL SCIENCE

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

(2016) Yu Liu et al.   NATURE

Autophagy controls centrosome number by degrading Cep63

(2016) Yuichiro Watanabe et al.   Nature Communications

Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube

(2016) M. A. Eckert et al.   Cancer Discovery

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing

(2016) Alexander J. Cole et al.   Scientific Reports

Autophagy positively regulates DNA damage recognition by nucleotide excision repair

(2015) Lei Qiang et al.   Autophagy

Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling

(2015) Joseph M Foster et al.   BMC Medical Genomics

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro

(2015) Rohann J. M. Correa et al.   Journal of Ovarian Research

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer

(2015) Joe R Delaney et al.   Oncotarget

Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

(2015) Roland F. Schwarz et al.   PLOS MEDICINE

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

(2015) Hao Tang et al.   EBioMedicine

Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines

(2015) Michael I. Koukourakis et al.   PLoS One

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity

(2014) Michelle Cicchini et al.   Autophagy

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

Beclin-1 is required for chromosome congression and proper outer kinetochore assembly

(2013) Stéphane Frémont et al.   EMBO REPORTS

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

DNA damage by reactive species: Mechanisms, mutation and repair

(2012) N R Jena   JOURNAL OF BIOSCIENCES

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mechanisms of BRCA1 Tumor Suppression: Figure 1.

(2012) Daniel P. Silver et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Glycerophospholipid Synthesis as a Novel Drug Target Against Cancer

(2011) Vincenza Dolce et al.   Current Molecular Pharmacology

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL