Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials

Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis

(2019) Sulav Duwal et al.   PLoS Computational Biology

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge

(2019) Amarendra Pegu et al.   Cell Host & Microbe

Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections

(2018) Kshitij Wagh et al.   PLoS Pathogens

A single, continuous metric to define tiered serum neutralization potency against HIV

(2018) Peter Hraber et al.   eLife

The averted infections ratio: a novel measure of effectiveness of experimental HIV pre-exposure prophylaxis agents

(2018) David T Dunn et al.   Lancet HIV

Use of broadly neutralizing antibodies for HIV-1 prevention

(2017) Amarendra Pegu et al.   IMMUNOLOGICAL REVIEWS

Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys

(2017) Boris Julg et al.   JOURNAL OF VIROLOGY

Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia

(2017) Daniel B. Reeves et al.   JOURNAL OF VIROLOGY

Early antibody therapy can induce long-lasting immunity to SHIV

(2017) Yoshiaki Nishimura et al.   NATURE

Preventing acquisition of HIV is the only path to an AIDS-free generation

(2017) Lawrence Corey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the duration of the period between exposure to HIV and detectable infection

(2017) Bernhard P. Konrad et al.   Epidemics

Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial

(2017) Kenneth H. Mayer et al.   PLOS MEDICINE

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters

(2017) Oliver F. Brandenberg et al.   PLoS Pathogens

Anti-proliferative therapy for HIV cure: a compound interest approach

(2017) Daniel B. Reeves et al.   Scientific Reports

HIV-Host Interactions: Implications for Vaccine Design

(2016) Barton F. Haynes et al.   Cell Host & Microbe

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

(2016) Stephan Halle et al.   IMMUNITY

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

(2016) Johannes F. Scheid et al.   NATURE

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

(2016) Rajeev Gautam et al.   NATURE

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

(2016) Ann J Hessell et al.   NATURE MEDICINE

Antiretroviral Therapy for the Prevention of HIV-1 Transmission

(2016) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

(2016) Jinyan Liu et al.   SCIENCE

Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes

(2016) Joshua T. Schiffer et al.   Science Translational Medicine

Residual Viremia in Treated HIV+ Individuals

(2016) Jessica M. Conway et al.   PLoS Computational Biology

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection

(2016) Korey R. Demers et al.   PLoS Pathogens

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

(2016) Kshitij Wagh et al.   PLoS Pathogens

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

(2015) J. E. Ledgerwood et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

What do mathematical models tell us about killing rates during HIV-1 infection?

(2015) Saikrishna Gadhamsetty et al.   IMMUNOLOGY LETTERS

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

(2015) Rebecca M. Lynch et al.   JOURNAL OF VIROLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

(2015) Holly Janes et al.   NATURE MEDICINE

CATNAP: a tool to compile, analyze and tally neutralizing antibody panels

(2015) Hyejin Yoon et al.   NUCLEIC ACIDS RESEARCH

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

(2015) Rebecca M. Lynch et al.   Science Translational Medicine

Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

(2015) Nicholas E. Webb et al.   Nature Communications

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

(2015) Laura E. McCoy et al.   PLoS Pathogens

Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes

(2014) Rui Kong et al.   JOURNAL OF VIROLOGY

The Majority of CD4+ T-Cell Depletion during Acute Simian-Human Immunodeficiency Virus SHIV89.6P Infection Occurs in Uninfected Cells

(2014) L. Matrajt et al.   JOURNAL OF VIROLOGY

A mechanistic theory to explain the efficacy of antiretroviral therapy

(2014) Sarah B. Laskey et al.   NATURE REVIEWS MICROBIOLOGY

In vivo protection by broadly neutralizing HIV antibodies

(2014) Marit J. van Gils et al.   TRENDS IN MICROBIOLOGY

Modeling the within-host dynamics of HIV infection

(2013) Alan S Perelson et al.   BMC BIOLOGY

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

A novel acute HIV infection staging system based on 4th generation immunoassay

(2013) Jintanat Ananworanich et al.   Retrovirology

Stochastic Analysis of Pre- and Postexposure Prophylaxis against HIV Infection

(2013) Jessica M. Conway et al.   SIAM JOURNAL ON APPLIED MATHEMATICS

Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1–Serodiscordant Couples

(2012) James P. Hughes et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

(2012) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

(2012) B. Moldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute HIV-1 Infection

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stochastic Theory of Early Viral Infection: Continuous versus Burst Production of Virions

(2011) John E. Pearson et al.   PLoS Computational Biology

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

The Detection of Acute HIV Infection

(2010) Myron S. Cohen et al.   JOURNAL OF INFECTIOUS DISEASES

Estimation of the Initial Viral Growth Rate and Basic Reproductive Number during Acute HIV-1 Infection

(2010) R. M. Ribeiro et al.   JOURNAL OF VIROLOGY

Low-Dose Mucosal Simian Immunodeficiency Virus Infection Restricts Early Replication Kinetics and Transmitted Virus Variants in Rhesus Monkeys

(2010) J. Liu et al.   JOURNAL OF VIROLOGY

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

(2010) Robert M. Grant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

(2009) Nilu Goonetilleke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies

(2009) Marie-Claude Boily et al.   LANCET INFECTIOUS DISEASES

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

(2009) Ann J Hessell et al.   NATURE MEDICINE