CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms

(2015) Bani Mukhopadhyay et al.   HEPATOLOGY

Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow–Derived Monocytes/Macrophages in a CB1-Dependent Manner

(2015) Ping Mai et al.   JOURNAL OF IMMUNOLOGY

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats

(2015) Eugene Chang   WORLD JOURNAL OF GASTROENTEROLOGY

Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity

(2014) Joseph Tam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue

(2013) Jialin Xu et al.   PLoS One

Severe asymptomatic non-alcoholic fatty liver disease in routine diabetes care; a multi-disciplinary team approach to diagnosis and management

(2013) Matthew J. Armstrong et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

(2013) Miguel A. Lanaspa et al.   Nature Communications

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

(2012) Geoffrey C. Farrell et al.   Gut and Liver

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant

(2011) M. A. Bergstrom et al.   DRUG METABOLISM AND DISPOSITION

Prevalence and markers of advanced liver disease in type 2 diabetes

(2011) R. M. Williamson et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C

(2010) Carmelo García-Monzón et al.   JOURNAL OF HEPATOLOGY

Pathology of nonalcoholic fatty liver disease

(2010) Elizabeth M. Brunt   Nature Reviews Gastroenterology & Hepatology

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The multiple functions of the endocannabinoid system: a focus on the regulation of food intake

(2010) Eduardo Tibiriça   Diabetology & Metabolic Syndrome

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

(2009) Hirokazu Sugimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adiponectin is required to mediate rimonabant-induced improvement of insulin sensitivity but not body weight loss in diet-induced obese mice

(2009) Stéphanie Migrenne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The role of the endocannabinoid system in liver diseases

(2009) Paolo Caraceni et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

(2009) X.-N. Li et al.   DIABETES

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients

(2009) Riccardo Sarzani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Paracrine Activation of Hepatic CB1 Receptors by Stellate Cell-Derived Endocannabinoids Mediates Alcoholic Fatty Liver

(2008) Won-il Jeong et al.   Cell Metabolism

Inflammatory Pathways in Liver Homeostasis and Liver Injury

(2008) Frank Tacke et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION