Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

(2018) Thomas Goiran et al.   CELL DEATH AND DIFFERENTIATION

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

(2018) Robert J. Ihry et al.   NATURE MEDICINE

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Oxidative stress preconditioning of mouse perivascular myogenic progenitors selects a subpopulation of cells with a distinct survival advantage in vitro and in vivo

(2018) Cesare Gargioli et al.   Cell Death & Disease

Tumor suppressive role for kinases phosphorylating p53 in the DNA damage-induced apoptosis

(2018) Satomi Yogosawa et al.   CANCER SCIENCE

Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

(2018) Xiao-Lan Li et al.   NUCLEIC ACIDS RESEARCH

Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells

(2018) Jianli Guo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner

(2016) Ping Zhang et al.   Scientific Reports

Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells

(2015) Syu-ichi Kanno et al.   TOXICOLOGY LETTERS

Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1

(2015) Lei Wei et al.   PLoS One

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

Tracking cancer drugs in living cells by thermal profiling of the proteome

(2014) M. M. Savitski et al.   SCIENCE

Induction of p53-Dependent p21 Limits Proliferative Activity of Rat Hepatocytes in the Presence of Hepatocyte Growth Factor

(2013) Yukiko Inoue et al.   PLoS One

A p38mapk-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells

(2013) Y Hadjal et al.   Cell Death & Disease

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

(2012) Young Min Chung et al.   Nature Communications

The transcription-independent mitochondrial p53 program is a major contributor to Nutlin-induced apoptosis in tumor cells

(2011) Angelina V. Vaseva et al.   CELL CYCLE

p53 Rescue through HDM2 Antagonism Suppresses Melanoma Growth and Potentiates MEK Inhibition

(2011) Zhenyu Ji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β

(2011) María Luisa Fernández-Cruz et al.   LIFE SCIENCES

Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53

(2010) A K Arya et al.   BRITISH JOURNAL OF CANCER

Persistent p21 Expression after Nutlin-3a Removal Is Associated with Senescence-like Arrest in 4N Cells

(2010) Hong Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delayed treatment with a p53 inhibitor enhances recovery in stroke brain

(2009) Yu Luo et al.   ANNALS OF NEUROLOGY

Pifithrin-α protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53

(2009) D Sohn et al.   CELL DEATH AND DIFFERENTIATION

A complex barcode underlies the heterogeneous response of p53 to stress

(2008) Fiona Murray-Zmijewski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY