TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice

Progressive loss of muscle mass could be an adverse prognostic factor of 28-day mortality in septic shock patients

(2019) Dong-Woo Seo et al.   Scientific Reports

TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia

(2018) Kevin G. Burfeind et al.   BRAIN BEHAVIOR AND IMMUNITY

Incidence and outcomes of sepsis after cardiac surgery as defined by the Sepsis-3 guidelines

(2018) S.H. Howitt et al.   BRITISH JOURNAL OF ANAESTHESIA

Shisa2 regulates the fusion of muscle progenitors

(2018) Zuojun Liu et al.   Stem Cell Research

Epidemiology and Costs of Sepsis in the United States—An Analysis Based on Timing of Diagnosis and Severity Level

(2018) Carly J. Paoli et al.   CRITICAL CARE MEDICINE

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle

(2018) Xiaofan Yang et al.   Cell Communication and Signaling

Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α

(2017) Yuko Ono et al.   PLoS One

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

(2017) Guohua Zhang et al.   Nature Communications

Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways

(2017) Guohua Zhang et al.   Scientific Reports

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Key Role of DAMP in Inflammation, Cancer, and Tissue Repair

(2016) Franco Pandolfi et al.   CLINICAL THERAPEUTICS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

(2016) Mark E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

Toll-like receptor 4 signalling mediates inflammation in skeletal muscle of patients with chronic kidney disease

(2016) Daniela Verzola et al.   Journal of Cachexia Sarcopenia and Muscle

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Cytokine profile in severe gram-positive and gram-negative abdominal sepsis

(2015) Maja Surbatovic et al.   Scientific Reports

Acute Outcomes and 1-Year Mortality of Intensive Care Unit–acquired Weakness. A Cohort Study and Propensity-matched Analysis

(2014) Greet Hermans et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging

(2014) S. Ghosh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults

(2013) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas

(2013) Melissa Kang et al.   BMC CANCER

Cancer- and endotoxin-induced cachexia require intact glucocorticoid signaling in skeletal muscle

(2013) Theodore P. Braun et al.   FASEB JOURNAL

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Lipopolysaccharide on Inflammation and Insulin Action in Human Muscle

(2013) Hanyu Liang et al.   PLoS One

Toll-like Receptor 4 Signaling in Ventilator-induced Diaphragm Atrophy

(2012) Willem-Jan M. Schellekens et al.   ANESTHESIOLOGY

Molecular and cellular mechanisms of skeletal muscle atrophy: an update

(2012) Alessandro Fanzani et al.   Journal of Cachexia Sarcopenia and Muscle

Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes

(2011) R. Tarabees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Toll-Like Receptor 4 Inhibitor TAK-242 Attenuates Acute Kidney Injury in Endotoxemic Sheep

(2011) Johan Fenhammar et al.   ANESTHESIOLOGY

C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

(2011) Guohua Zhang et al.   EMBO JOURNAL

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Postoperative Sepsis in the United States

(2010) Todd R. Vogel et al.   ANNALS OF SURGERY

Circulating Endotoxemia: A Novel Factor in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease

(2010) C. W. McIntyre et al.   Clinical Journal of the American Society of Nephrology

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways

(2010) Alexander Doyle et al.   FASEB JOURNAL

Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury

(2010) Hiroyuki Seki et al.   INFLAMMATION RESEARCH

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Combination of Imipenem and TAK-242, a Toll-Like Receptor 4 Signal Transduction Inhibitor, Improves Survival in a Murine Model of Polymicrobial Sepsis

(2010) Takukyu Sha et al.   SHOCK

Intensive care unit-acquired weakness (ICUAW) and muscle wasting in critically ill patients with severe sepsis and septic shock

(2010) Joerg C. Schefold et al.   Journal of Cachexia Sarcopenia and Muscle

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

Involvement of Na+/Ca2+exchanger in migration and contraction of rat cultured tendon fibroblasts

(2009) Kazuho Sakamoto et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acquired Weakness, Handgrip Strength, and Mortality in Critically Ill Patients

(2008) Naeem A. Ali et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes

(2008) Michael Menconi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]

(2008) A. Satow et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS