Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery
Authors
Keywords
-
Journal
Scientific Reports
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-12-09
DOI
10.1038/s41598-019-55136-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Distinct progression patterns of brain disease in infantile and juvenile gangliosidoses: Volumetric quantitative MRI study
- (2018) Igor Nestrasil et al. MOLECULAR GENETICS AND METABOLISM
- Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial
- (2018) Roberto Giugliani et al. Orphanet Journal of Rare Diseases
- Types A and B Niemann-Pick disease
- (2017) Edward H. Schuchman et al. MOLECULAR GENETICS AND METABOLISM
- Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse–Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse
- (2017) Ruben J. Boado et al. MOLECULAR PHARMACEUTICS
- Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody–Iduronidase Fusion Protein
- (2017) Ruben J. Boado et al. MOLECULAR PHARMACEUTICS
- Histochemical localization of palmitoyl protein thioesterase-1 activity
- (2016) Joshua T. Dearborn et al. MOLECULAR GENETICS AND METABOLISM
- Enzyme replacement for GM1-gangliosidosis: Uptake, lysosomal activation, and cellular disease correction using a novel β-galactosidase:RTB lectin fusion
- (2016) Jose Condori et al. MOLECULAR GENETICS AND METABOLISM
- Insulin Receptor Antibody−α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts
- (2016) Ruben J. Boado et al. MOLECULAR PHARMACEUTICS
- Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo
- (2016) Michael B Tropak et al. Molecular Therapy-Methods & Clinical Development
- Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan
- (2015) Cara M. Weismann et al. HUMAN MOLECULAR GENETICS
- Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis
- (2015) Jui-Yun Lu et al. MOLECULAR GENETICS AND METABOLISM
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Pathogenesis and therapies for infantile neuronal ceroid lipofuscinosis (infantile CLN1 disease)
- (2013) Jacqueline A. Hawkins-Salsbury et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Clinical Neurogenetics
- (2013) Gregory M. Pastores et al. NEUROLOGIC CLINICS
- Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl–protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis
- (2012) Jie Hu et al. MOLECULAR GENETICS AND METABOLISM
- Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A
- (2012) Jie Bu et al. MOLECULAR THERAPY
- Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion
- (2011) Robin J. Ziegler et al. EXPERIMENTAL NEUROLOGY
- Crystal Structure of Human β-Galactosidase
- (2011) Umeharu Ohto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reversal of Lysosomal Storage in Brain of Adult MPS-I Mice with Intravenous Trojan Horse-Iduronidase Fusion Protein
- (2011) Ruben J. Boado et al. MOLECULAR PHARMACEUTICS
- Genetic engineering of IgG-glucuronidase fusion proteins
- (2009) Ruben J. Boado et al. JOURNAL OF DRUG TARGETING
- Neurodegenerative lysosomal storage disease in European Burmese cats with hexosaminidase β-subunit deficiency
- (2009) Allison M. Bradbury et al. MOLECULAR GENETICS AND METABOLISM
- Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis
- (2009) Jui-Yun Lu et al. MOLECULAR GENETICS AND METABOLISM
- Neural Stem Cell Transplantation Benefits a Monogenic Neurometabolic Disorder During the Symptomatic Phase of Disease
- (2009) Mylvaganam Jeyakumar et al. STEM CELLS
- Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann–Pick A disease
- (2008) James C. Dodge et al. EXPERIMENTAL NEUROLOGY
- Generation and characterization of recombinant feline β-galactosidase for preclinical enzyme replacement therapy studies in GM1 gangliosidosis
- (2008) Tatiana I. Samoylova et al. METABOLIC BRAIN DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search