Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

(2016) Yoshinori Takeuchi et al.   Cell Reports

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

(2015) Shuxin Han et al.   Nature Communications

KLF15 Establishes the Landscape of Diurnal Expression in the Heart

(2015) Lilei Zhang et al.   Cell Reports

Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism

(2014) Domenick A. Prosdocimo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Insulin resistance and the metabolism of branched-chain amino acids

(2013) Jingyi Lu et al.   Frontiers of Medicine

Klf15 Orchestrates Circadian Nitrogen Homeostasis

(2012) Darwin Jeyaraj et al.   Cell Metabolism

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation

(2012) S. M. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

(2012) G. Novarino et al.   SCIENCE

Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?

(2011) Y. Huang et al.   CARDIOVASCULAR RESEARCH

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

(2010) Cédric Chaveroux et al.   BIOCHIMIE

Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

(2010) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling

(2010) Irantzu Tato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism