Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
Authors
Keywords
-
Journal
Nature Communications
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-01-21
DOI
10.1038/s41467-019-13928-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia
- (2017) Vincent Hayes et al. JOURNAL OF CLINICAL INVESTIGATION
- Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα
- (2017) Yunmei Wang et al. Nature Communications
- High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular Design
- (2017) Antonella Paladino et al. PLoS Computational Biology
- Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?
- (2017) Marion Lavergne et al. Cancers
- Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores
- (2016) Z. Elaib et al. BLOOD
- Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)
- (2016) Zhaohua Zheng et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The Platelet Integrin αIIbβ3 Differentially Interacts with FibrinVersusFibrinogen
- (2016) Rustem I. Litvinov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integrin-based therapeutics: biological basis, clinical use and new drugs
- (2016) Klaus Ley et al. NATURE REVIEWS DRUG DISCOVERY
- A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation
- (2015) Rudy E. Fuentes et al. JOURNAL OF CLINICAL INVESTIGATION
- Reassignment of a rare sense codon to a non-canonical amino acid inEscherichia coli
- (2015) Takahito Mukai et al. NUCLEIC ACIDS RESEARCH
- RUC-4
- (2014) Jihong Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Correlates of poor outcome among patients with bleeding after coronary interventions
- (2014) Gjin Ndrepepa et al. CORONARY ARTERY DISEASE
- Novel antiplatelet agents in acute coronary syndrome
- (2014) Francesco Franchi et al. Nature Reviews Cardiology
- Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
- (2014) Johannes F Van Agthoven et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?
- (2013) J. D. Hohmann et al. BLOOD
- The Interaction of Integrin αIIbβ3with Fibrin Occurs through Multiple Binding Sites in the αIIbβ-Propeller Domain
- (2013) Nataly P. Podolnikova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A directional switch of integrin signalling and a new anti-thrombotic strategy
- (2013) Bo Shen et al. NATURE
- Full reconstitution of human platelets in humanized mice after macrophage depletion
- (2012) Z. Hu et al. BLOOD
- Vorapaxar in the Secondary Prevention of Atherothrombotic Events
- (2012) David A. Morrow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
- (2012) J. Zhu et al. Science Translational Medicine
- Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans
- (2011) Martin Ungerer et al. CIRCULATION
- Humanized Mouse Model of Thrombosis Is Predictive of the Clinical Efficacy of Antiplatelet Agents
- (2011) Jorge Magallon et al. CIRCULATION
- Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis—But Does Not Affect Immunity and Thrombosis in Mice
- (2011) Dennis Wolf et al. CIRCULATION RESEARCH
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Talin-dependent integrin activation is required for fibrin clot retraction by platelets
- (2010) J. R. Haling et al. BLOOD
- Cystine-knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation
- (2010) Adam P. Silverman et al. JOURNAL OF MOLECULAR RECOGNITION
- Integrin Priming Dynamics: Mechanisms of Integrin Antagonist-Promoted αIIbβ3:PAC-1 Molecular Recognition
- (2009) Roy R. Hantgan et al. BIOCHEMISTRY
- Function and Antagonism of β Integrins in the Development of Cancer Therapy
- (2009) H. Sheldrake et al. CURRENT CANCER DRUG TARGETS
- Renal allograft thrombosis
- (2009) C. Ponticelli et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes
- (2009) Lars Wallentin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism
- (2009) Meredith W. Miller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The GPIIb/IIIa (integrin IIb 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
- (2008) B. S. Coller et al. BLOOD
- Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3
- (2008) Timothy A. Springer et al. JOURNAL OF CELL BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now