Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

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Codon-specific translation reprogramming promotes resistance to targeted therapy

(2018) Francesca Rapino et al.   NATURE

Deletion 6q drives T-cell leukemia progression by ribosome modulation

(2018) Stéphanie Gachet et al.   Cancer Discovery

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

(2017) Ly P Vu et al.   NATURE GENETICS

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miR-218-5p restores sensitivity to gemcitabine through PRKCE/MDR1 axis in gallbladder cancer

(2017) Hui Wang et al.   Cell Death & Disease

Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer

(2017) Chien-Hsien Lai et al.   Cell Death & Disease

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer

(2016) Jiangning Gu et al.   CANCER LETTERS

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

(2016) Sylvain Delaunay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK

(2015) Tomohiro Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway

(2015) Maolan Li et al.   CANCER SCIENCE

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

Gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) Yoav Binenbaum et al.   DRUG RESISTANCE UPDATES

Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression

(2015) Dong Gwang Lee et al.   JOURNAL OF HEPATOLOGY

Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage

(2015) Marie-Jo Halaby et al.   MOLECULAR AND CELLULAR BIOLOGY

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(2015) Nicolas Stransky et al.   NATURE

p53, a translational regulator: contribution to its tumour-suppressor activity

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Phenoxodiol Enhances the Antitumor Activity of Gemcitabine in Gallbladder Cancer Through Suppressing Akt/mTOR Pathway

(2014) Yu Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma

(2014) Da Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents

(2014) Magdalena Klanova et al.   Molecular Cancer

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

(2014) Yuexin Zhou et al.   NATURE

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

(2014) Kiruthika Selvadurai et al.   Nature Chemical Biology

Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway

(2014) Maolan Li et al.   NATURE GENETICS

Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer

(2013) Shigeru Horiguchi et al.   Molecular Oncology

The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA

(2013) S Weingarten-Gabbay et al.   ONCOGENE

Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo

(2013) JINGHAN WANG et al.   ONCOLOGY REPORTS

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy

(2013) R Hill et al.   Cell Death & Disease

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

(2013) Jorge Fernández-Vázquez et al.   PLoS Genetics

hnRNP Q regulates translation of p53 in normal and stress conditions

(2012) D-Y Kim et al.   CELL DEATH AND DIFFERENTIATION

Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor

(2012) STEVEN G. GRAY et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

(2012) Pierre Close et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase

(2012) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Annexin A2 and PSF proteins interact with p53 IRES and regulate translation of p53 mRNA

(2012) Arandkar Sharathchandra et al.   RNA Biology

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

(2011) Erwin van den Born et al.   Nature Communications

Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation

(2010) Lorenzo Montanaro et al.   CANCER RESEARCH

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer

(2010) Juan Valle et al.   NEW ENGLAND JOURNAL OF MEDICINE

hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb α via IRES-mediated translation

(2010) Do-Yeon Kim et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY