Article
Chemistry, Multidisciplinary
Ruoyu Shen, Lijun Peng, Wentao Zhou, Ding Wang, Qi Jiang, Jian Ji, Fuqiang Hu, Hong Yuan
Summary: Abnormal tumor vasculature leads to malignant tumor microenvironment and affects tumor progression. We developed a nano-delivery system that sustains the release of anti-angiogenic agents to stabilize tumor vascular normalization, improving tumor perfusion and reversing abnormalities in the tumor microenvironment, ultimately inhibiting tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Gastroenterology & Hepatology
Guido Carpino, Vincenzo Cardinale, Alessandra Di Giamberardino, Diletta Overi, Samantha Donsante, Tania Colasanti, Gaia Amato, Gianluca Mennini, Matteo Franchitto, Fabrizio Conti, Massimo Rossi, Mara Riminucci, Eugenio Gaudio, Domenico Alvaro, Carmine Mancone
Summary: The study identified THBS1, THBS2, and PEDF released in iCCA inhibit vessel growth and promote tumor-associated lymphangiogenesis, offering potential targets for interventions to counteract the dissemination process in iCCA.
JOURNAL OF HEPATOLOGY
(2021)
Review
Oncology
Ruiqi Zheng, Feifan Li, Fengcen Li, Aihua Gong
Summary: Tumor recurrence often results from an abnormal microenvironment, such as the presence of pro-angiogenic factors and lack of pro-maturation factors in the tumor microenvironment. The coexistence of perfusion and hypoxic zones, as well as uneven blood vessel distribution, profoundly influence tumor development. Vascular normalization therapy can improve tumor oxygenation and substance transport, leading to better treatment outcomes and fewer side effects.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Kai Wang, Qinhua Chen, Nanxin Liu, Jie Zhang, Xiaoyan Pan
Summary: One major issue in cancer treatment is resistance to chemotherapeutic drugs, often associated with abnormal blood vessels. Jain's vascular normalization theory has been applied effectively to drug-resistant tumor treatment. By using angiogenesis inhibitors, remodeling abnormal vessel structure and function can maximize the efficacy of chemotherapeutic drugs.
DRUG DISCOVERY TODAY
(2021)
Article
Oncology
Jack Lawler
Summary: Considerable progress has been made in understanding angiogenesis in normal and tumor tissue. The success of anti-angiogenic treatments has been limited so far, but it is expected to improve with the development of therapies targeting other pathways and a better understanding of resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Elie Marcheteau, Thomas Farge, Michael Peres, Guillaume Labrousse, Julie Tenet, Stephanie Delmas, Maud Chusseau, Raphaelle Duprez-Paumier, Camille Franchet, Florence Dalenc, Caroline Imbert, Justine Noujarede, Celine Colacios, Herve Prats, Florence Cabon, Bruno Segui
Summary: TSP1 plays a crucial role in TNBC by influencing TILs content and immunotherapy efficacy, making it a potential therapeutic target in combination with immunotherapy for TNBC treatment.
Review
Biochemistry & Molecular Biology
Sukhbir Kaur, Steven M. Bronson, Dipasmita Pal-Nath, Thomas W. Miller, David R. Soto-Pantoja, David D. Roberts
Summary: Thrombospondin-1 has diverse roles in cancer biology, including regulating angiogenesis, immune suppression, and genotoxic stress responses. Challenges remain in harnessing its therapeutic potential in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Xu Xin Sun, Zeynab Nosrati, Janell Ko, Che-Min Lee, Kevin L. Bennewith, Marcel B. Bally
Summary: Immunotherapy has revolutionized cancer treatment, but there is a need for further improvements to enhance its positive benefits. Our team believes that combining drug delivery methods with the right small-molecule drugs can help double the overall survival rate for patients receiving immunotherapeutics.
Article
Immunology
Jieying Yang, Zhixing Guo, Mengjia Song, Qiuzhong Pan, Jingjing Zhao, Yue Huang, Yulong Han, Dijun Ouyang, Chaopin Yang, Hao Chen, Muping Di, Yan Tang, Qian Zhu, Qijing Wang, Yongqiang Li, Jia He, Desheng Weng, Tong Xiang, JianChuan Xia
Summary: This study investigated the optimal method and underlying mechanisms for combining lenvatinib and anti-PD-1 antibody, and found that an optimal dose of lenvatinib can normalize tumor vasculature and increase immune cell infiltration. It enhances the integrity of endothelial cells and promotes the interaction between endothelial cells and pericytes to suppress tumor growth.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Manale Karam, Annette Ives, Christian Auclair
Summary: This paper proposes a novel approach for inducing tumor vascular normalization and reducing hypoxia in cancer patients through the pharmacological modulation of plasma S1P levels. The approach is based on clinical observations and pre-clinical data, supported by a review of the biological role of S1P in vascular functionality regulation. The results suggest that tumor vasculature normalization could be an effective strategy to enhance therapy efficacy in solid tumors.
Review
Biochemistry & Molecular Biology
Yixiao Pan, Lu Deng, Hai Wang, Kang He, Qiang Xia
Summary: Histidine-rich glycoprotein (HRGP) is a glycoprotein abundant in plasma with a multidomain structure, allowing it to interact with various ligands and regulate biological processes. HRGP acts as an extracellular adaptor protein, connecting with different ligands such as heme, Zn2+, thrombospondin.
Article
Endocrinology & Metabolism
Mei-mei Liu, Xiu-hui Chen, Xiu-min Lu, Fang-fang Wang, Chao Wang, Yu Liu, Pei-ling Li, Bo-tao Du, Sha Liang, Pi-dong Gong, Yu-xin Wang
Summary: The study found that markers of angiogenesis in PCOS patients were expressed differently and they responded differently to the treatment with oral contraception Diane-35. After treatment, some physiological indicators of the patients changed, but the changes were not consistent among all individuals. Further research is needed to draw more definitive conclusions in this field.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wen Li, Jin-Xuan Fan, Ji-Yan Qiao, Qi-Wen Chen, Yun-Xia Sun, Xian-Zheng Zhang
Summary: In this study, a sulfhydryl hyaluronid-based hydrogel (HA-SH) was synthesized and Thiobacillus denitrificans was loaded into the hydrogel to target the colon. The loaded bacteria can scavenge excess H2S in colon cancer, promoting tumor vascular normalization and improving the delivery of chemotherapy drug CPT to inhibit tumor progression. Both in vivo and in vitro experiments showed the satisfactory effects of the self-crosslinked bacterial hydrogel in inhibiting tumor progression and promoting tumor vascular normalization in colon cancer.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Christine M. Sorenson, Shoujian Wang, Soesiawati R. Darjatmoko, Zafer Gurel, Bo Liu, Nader Sheibani
Summary: TSP1 is a vital regulator of angiogenesis and inflammation in the eye, with its loss contributing to increased retinal vascular density and pathological ocular neovascularization. The study found that while global knockout of TSP1 led to increased retinal vascular density, only lack of TSP1 expression in endothelial cells was sufficient to increase choroidal neovascularization. Individual cell type loss of TSP1 resulted in decreased retinal endothelial cell numbers in a cell type-specific manner, highlighting the unique role TSP1 plays in each cell type.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Andreas Bikfalvi, Joris Guyon, Thomas Daubon
Summary: Glioblastoma is a highly aggressive and vascularized malignancy. Recent studies have shown the important role of thrombospondin-1 in the development of glioblastoma.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)