Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

(2019) Yves Dondelinger et al.   Nature Communications

Rapid Progression of Adult T-Cell Leukemia–Lymphoma after PD-1 Inhibitor Therapy

(2018) Lee Ratner et al.   NEW ENGLAND JOURNAL OF MEDICINE

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma

(2017) Lucy B. Cook et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1

(2016) Christiane Koppe et al.   HEPATOLOGY

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease

(2016) H van Andel et al.   ONCOGENE

More to Life than NF-κB in TNFR1 Signaling

(2016) Adrian T. Ting et al.   TRENDS IN IMMUNOLOGY

Adult T-cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy

(2016) Monica Zell et al.   Oncotarget

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

(2016) Diana Legarda et al.   Cell Reports

ATL treatment: is it time to change?

(2015) O. Hermine   BLOOD

Treatment and survival among 1594 patients with ATL

(2015) H. Katsuya et al.   BLOOD

Promises and Challenges of Smac Mimetics as Cancer Therapeutics

(2015) S. Fulda   CLINICAL CANCER RESEARCH

Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1

(2015) Scott J. Justus et al.   IMMUNOLOGICAL REVIEWS

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?

(2015) Charles RM Bangham et al.   Current Opinion in Virology

Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP

(2014) A Bazarbachi et al.   BONE MARROW TRANSPLANTATION

Co-dependence of HTLV-1 p12 and p8 Functions in Virus Persistence

(2014) Cynthia A. Pise-Masison et al.   PLoS Pathogens

Inactivation of BAD by IKK Inhibits TNFα-Induced Apoptosis Independently of NF-κB Activation

(2013) Jie Yan et al.   CELL

Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT)

(2013) D Chihara et al.   Blood Cancer Journal

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study

(2012) Takashi Ishida et al.   JOURNAL OF CLINICAL ONCOLOGY

HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways

(2012) Robert Currer et al.   Frontiers in Microbiology

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

(2011) M Darding et al.   CELL DEATH AND DIFFERENTIATION

RIP1 comes back to life as a cell death regulator in TNFR1 signaling

(2011) Marie Anne O’Donnell et al.   FEBS Journal

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF- B Activation

(2011) S. Rosebeck et al.   SCIENCE

Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis

(2011) Zhaoxia Qu et al.   Viruses-Basel

SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds

(2011) H H Cheung et al.   Cell Death & Disease

Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax

(2011) Xuefeng Wu et al.   Cell and Bioscience

The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia

(2010) Lluis Espinosa et al.   CANCER CELL

Chronicles of a death foretold: Dual sequential cell death checkpoints in TNF signaling

(2010) Marie Anne O’Donnell et al.   CELL CYCLE

Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes

(2010) Ali Bazarbachi et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma

(2010) Kazuhito Yamamoto et al.   JOURNAL OF CLINICAL ONCOLOGY

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

(2010) N. Van Prooyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

(2009) Ramin Massoumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation

(2009) Jessica E. Hutti et al.   MOLECULAR CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

(2008) Kunihiro Tsukasaki et al.   JOURNAL OF CLINICAL ONCOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL