SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

(2010) B L Probst et al.   CELL DEATH AND DIFFERENTIATION

Small-molecule pan-IAP antagonists: a patent review

(2010) John A Flygare et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

(2009) Chudi Ndubaku et al.   ACS Chemical Biology

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

(2009) H. H. Cheung et al.   CANCER RESEARCH

Assembling the building blocks: structure and function of inhibitor of apoptosis proteins

(2009) P D Mace et al.   CELL DEATH AND DIFFERENTIATION

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

(2009) A Weber et al.   CELL DEATH AND DIFFERENTIATION

Kinome Sirna Screen Identifies SMG-1 as a Negative Regulator of Hypoxia-inducible Factor-1α in Hypoxia

(2009) Run-Qiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

(2008) J. Lu et al.   CANCER RESEARCH

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Inhibitor of Apoptosis Proteins in Eukaryotic Evolution and Development: A Model of Thematic Conservation

(2008) Mary X.D. O'Riordan et al.   DEVELOPMENTAL CELL

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis

(2008) Vasco Oliveira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells

(2008) T R Wilson et al.   ONCOGENE

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

(2008) S C Gehen et al.   ONCOGENE

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of canonical NF- B activation through the NIK-IKK complex pathway

(2008) B. Zarnegar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA