Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer

Thymoquinone: fifty years of success in the battle against cancer models

(2013) Regine Schneider-Stock et al.   DRUG DISCOVERY TODAY

p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner

(2013) Zhipeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-κB Activation

(2013) Leo Lap-Yan Wong et al.   PLoS One

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

(2013) Chern Chiuh Woo et al.   PLoS One

Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic

(2012) Zhou Yin et al.   ACS Chemical Biology

Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer--Opportunities, Challenges, and Limitations

(2012) J. Eswaran et al.   CLINICAL CANCER RESEARCH

Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growthin vivo

(2012) Samir Attoub et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo

(2011) Xiaofei Lei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thymoquinone: Potential cure for inflammatory disorders and cancer

(2011) Chern Chiuh Woo et al.   BIOCHEMICAL PHARMACOLOGY

Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase

(2011) Jue Wang et al.   STRUCTURE

Signaling pathway networks mined from human pituitary adenoma proteomics data

(2010) Xianquan Zhan et al.   BMC Medical Genomics

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

(2010) Feng Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

PAK1 as a therapeutic target

(2010) Julia V Kichina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo

(2010) Syed H Jafri et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Colorectal cancer

(2010) David Cunningham et al.   LANCET

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

(2009) Nahed El-Najjar et al.   APOPTOSIS

Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer

(2009) Sanjeev Banerjee et al.   CANCER RESEARCH

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor CHEK1 and Contributes to Apoptosis in Colorectal Cancer Cells

(2008) H. Gali-Muhtasib et al.   CANCER RESEARCH

Targeting Nuclear Factor- B Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis

(2008) G. Sethi et al.   MOLECULAR CANCER RESEARCH

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

(2008) T. Yi et al.   MOLECULAR CANCER THERAPEUTICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH