A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration

Oxygen-induced alterations in the expression of chromatin modifying enzymes and the transcriptional regulation of imprinted genes

(2018) William M. Skiles et al.   GENE EXPRESSION PATTERNS

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

(2018) Takahiro Ito et al.   Cell Reports

Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes

(2018) Simona-Adriana Manea et al.   Redox Biology

Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization

(2018) Noriko Katoh et al.   Epigenomics

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

(2017) Wei Qi et al.   Nature Chemical Biology

The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

(2017) Pei Li et al.   Scientific Reports

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer

(2016) Zhongwei Li et al.   CELL DEATH AND DIFFERENTIATION

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway

(2016) Linwei Chen et al.   Scientific Reports

Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

(2015) Long Zhou et al.   JOURNAL OF PINEAL RESEARCH

The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes

(2015) F. S. Siddiqi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

(2015) Satoshi Suzuki et al.   ARTHRITIS RESEARCH & THERAPY

Notochord to Nucleus Pulposus Transition

(2015) Lisa Lawson et al.   Current Osteoporosis Reports

A genomics approach identifies senescence-specific gene expression regulation

(2014) Daniel H. Lackner et al.   AGING CELL

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

(2014) Gang Hou et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

Same-species phenotypic comparison of notochordal and mature nucleus pulposus cells

(2014) Taryn Saggese et al.   EUROPEAN SPINE JOURNAL

Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells

(2014) C S Manning et al.   ONCOGENE

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

(2014) Andrea Piunti et al.   Nature Communications

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

(2012) Sharad K. Verma et al.   ACS Medicinal Chemistry Letters

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration

(2011) Lucas A. Smolders et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression

(2011) T. Fan et al.   MOLECULAR CANCER RESEARCH

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling

(2011) Naoki Kondo et al.   SPINE

Direct Reprogramming of Melanocytes to Neural Crest Stem-Like Cells by One Defined Factor

(2011) Susan E. Zabierowski et al.   STEM CELLS

Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression

(2010) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM

Degeneration and regeneration of the intervertebral disc: lessons from development

(2010) L. J. Smith et al.   Disease Models & Mechanisms

The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell

(2010) Akihiko Hiyama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

(2010) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia

(2009) Xin Li et al.   AMERICAN JOURNAL OF PATHOLOGY

The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival

(2009) S. Balasubramanian et al.   CARCINOGENESIS

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

(2009) Elena Ezhkova et al.   CELL

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing

(2009) F. Tie et al.   DEVELOPMENT

Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals

(2009) Kenneth M. C. Cheung et al.   SPINE

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology