Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

Comparable Efficacy and Better Safety of Double β-Lactam Combination Therapy versus β-Lactam plus Aminoglycoside in Gram-negatives: A Meta-analysis of Randomized, Controlled Trials

(2019) Yuanyuan Jiao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

(2018) Dhruvitkumar S. Sutaria et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

(2017) Alexandre P. Zavascki et al.   Expert Review of Anti-Infective Therapy

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling

(2016) Rajbharan Yadav et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC

(2016) Etsuko Sugawara et al.   JOURNAL OF BACTERIOLOGY

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database

(2016) Baofeng Jia et al.   NUCLEIC ACIDS RESEARCH

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

(2015) Vincent M. Isabella et al.   CHEMISTRY & BIOLOGY

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

(2015) Shrenik C. Mehta et al.   PLoS Pathogens

Rapid detection of porins by matrix-assisted laser desorption/ionization-time of flight mass spectrometry

(2015) Yan-Yan Hu et al.   Frontiers in Microbiology

Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions

(2014) Michal Lipš et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains

(2013) Syamhanin Adnan et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

(2013) L Silvia Munoz-Price et al.   LANCET INFECTIOUS DISEASES

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of acquired antimicrobial resistance genes

(2012) E. Zankari et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii

(2012) E. Sugawara et al.   JOURNAL OF BACTERIOLOGY

Klebsiella pneumoniaeOuter Membrane Porins OmpK35 and OmpK36 Play Roles in both Antimicrobial Resistance and Virulence

(2011) Yu-Kuo Tsai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Relevance of Pharmacokinetic and Pharmacodynamic Modeling to Clinical Care of Critically Ill Patients

(2011) Jurgen B. Bulitta et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Effects of Hypoalbuminaemia on Optimizing Antibacterial Dosing in Critically Ill Patients

(2010) Marta Ulldemolins et al.   CLINICAL PHARMACOKINETICS

Characterization of Cellular Uptake of Perfluorooctanoate via Organic Anion-Transporting Polypeptide 1A2, Organic Anion Transporter 4, and Urate Transporter 1 for Their Potential Roles in Mediating Human Renal Reabsorption of Perfluorocarboxylates

(2010) Ching-Hui Yang et al.   TOXICOLOGICAL SCIENCES

Application of Basic Pharmacokinetic Concepts to Analysis of Microdialysis Data

(2009) Claire Dahyot et al.   CLINICAL PHARMACOKINETICS

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution

(2009) Jason A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

β-Lactam Resistance Response Triggered by Inactivation of a Nonessential Penicillin-Binding Protein

(2009) Bartolomé Moya et al.   PLoS Pathogens

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir

(2008) A. J. Parker et al.   DRUG METABOLISM AND DISPOSITION

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY