The regulatory cascades of antibiotic production in Streptomyces

Regulatory perspective of antibiotic biosynthesis in Streptomyces

(2019) Hanzhi Yin et al.   Science China-Life Sciences

Bidirectional Regulation of AdpAch in Controlling the Expression of scnRI and scnRII in the Natamycin Biosynthesis of Streptomyces chattanoogensis L10

(2018) Pin Yu et al.   Frontiers in Microbiology

Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

(2018) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Discovering potential Streptomyces hormone producers by using disruptants of essential biosynthetic genes as indicator strains

(2017) Nguyen B Thao et al.   JOURNAL OF ANTIBIOTICS

wblA , a pleiotropic regulatory gene modulating morphogenesis and daptomycin production in Streptomyces roseosporus

(2017) X. Huang et al.   JOURNAL OF APPLIED MICROBIOLOGY

DnrI of Streptomyces peucetius binds to the resistance genes, drrAB and drrC but is activated by daunorubicin

(2017) Francis Prija et al.   JOURNAL OF BASIC MICROBIOLOGY

Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene,adpA, inStreptomyces ansochromogenes

(2017) Jingjing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus

(2017) Shouliang Yin et al.   Science China-Life Sciences

A Novel TetR Family Transcriptional Regulator, CalR3, Negatively Controls Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882

(2017) Lixia Gou et al.   Frontiers in Microbiology

Crystallization and X-ray crystallographic analysis of recombinant TylP, a putative γ-butyrolactone receptor protein fromStreptomyces fradiae

(2017) Nurhikmah Mohd-Sharif et al.   Acta Crystallographica Section F-Structural Biology Communications

SlnR is a positive pathway-specific regulator for salinomycin biosynthesis in Streptomyces albus

(2016) Zhenhong Zhu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Gifted microbes for genome mining and natural product discovery

(2016) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors

(2016) Simon B. Fillenberg et al.   PLoS One

Transcriptional analysis of the cell division-related ssg genes in Streptomyces coelicolor reveals direct control of ssgR by AtrA

(2015) Songhee H. Kim et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis

(2015) Yvonne Mast et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of two novel regulatory genes involved in pristinamycin biosynthesis and elucidation of the mechanism for AtrA-p-mediated regulation in Streptomyces pristinaespiralis

(2015) Wenfang Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Multiple allosteric effectors control the affinity of DasR for its target sites

(2015) Elodie Tenconi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Butyrolactone signalling circuits for synthetic biology

(2015) Marc Biarnes-Carrera et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Transcriptional Regulation of the Daptomycin Gene Cluster inStreptomyces roseosporusby an Autoregulator, AtrA

(2015) Xu-Ming Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin byStreptomyces globisporus

(2015) Xingxing Li et al.   MOLECULAR MICROBIOLOGY

Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism

(2014) Aurélie Guyet et al.   BMC MICROBIOLOGY

Effect of Antibiotic Down-Regulatory Gene wblA Ortholog on Antifungal Polyene Production in Rare Actinomycetes Pseudonocardia autotrophica

(2014) Hye-Jin Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2)

(2014) Hussain Bhukya et al.   NUCLEIC ACIDS RESEARCH

Intriguing properties of the angucycline antibiotic auricin and complex regulation of its biosynthesis

(2013) Jan Kormanec et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

SsaA, a Member of a Novel Class of Transcriptional Regulators, Controls Sansanmycin Production in Streptomyces sp. Strain SS through a Feedback Mechanism

(2013) Q. Li et al.   JOURNAL OF BACTERIOLOGY

Two-component systems in Streptomyces: key regulators of antibiotic complex pathways

(2013) Héctor Rodríguez et al.   Microbial Cell Factories

The TetR Family of Regulators

(2013) L. Cuthbertson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genome-wide Distribution of AdpA, a Global Regulator for Secondary Metabolism and Morphological Differentiation in Streptomyces, Revealed the Extent and Complexity of the AdpA Regulatory Network

(2012) A. Higo et al.   DNA RESEARCH

A Two-Step Mechanism for the Activation of Actinorhodin Export and Resistance in Streptomyces coelicolor

(2012) Y. Xu et al.   mBio

Crp Is a Global Regulator of Antibiotic Production in Streptomyces

(2012) C. Gao et al.   mBio

SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors

(2012) Liliya Horbal et al.   AMB Express

Proteomic approach to enhance doxorubicin production in panK-integrated Streptomyces peucetius ATCC 27952

(2011) Eunjung Song et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Functional conservation of PAS–LuxR transcriptional regulators in polyene macrolide biosynthesis

(2011) Javier Santos-Aberturas et al.   METABOLIC ENGINEERING

Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor

(2011) Ana Yepes et al.   PLoS One

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis

(2011) S. Kitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

(2010) Juan-Francisco Martín et al.   CURRENT OPINION IN MICROBIOLOGY

“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis

(2010) Gangming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptomics analyses reveal global roles of the regulator AveI inStreptomyces avermitilis

(2009) Lei Chen et al.   FEMS MICROBIOLOGY LETTERS

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

(2009) Jia Guo et al.   MOLECULAR GENETICS AND GENOMICS

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Crystal Structures of the Streptomyces coelicolor TetR-Like Protein ActR Alone and in Complex with Actinorhodin or the Actinorhodin Biosynthetic Precursor (S)-DNPA

(2008) A.R. Willems et al.   JOURNAL OF MOLECULAR BIOLOGY

Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus

(2008) S. Hirano et al.   MICROBIOLOGY-SGM