Organelle contacts: Sub‐organelle zones to facilitate rapid and accurate inter‐organelle trafficking of lipids

Molecular determinants of ER–Golgi contacts identified through a new FRET–FLIM system

(2019) Rossella Venditti et al.   JOURNAL OF CELL BIOLOGY

Organelle Interplay - Peroxisome Interactions in Health and Disease

(2019) Michael Schrader et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

(2019) Wondwossen M Yeshaw et al.   eLife

Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis

(2019) Taki Nishimura et al.   MOLECULAR CELL

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

(2019) Chun-Yan Lim et al.   NATURE CELL BIOLOGY

ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

(2019) Ximing Du et al.   JOURNAL OF CELL BIOLOGY

Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites

(2018) Björn D.M. Bean et al.   JOURNAL OF CELL BIOLOGY

The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution

(2018) Tomoaki Sobajima et al.   JOURNAL OF CELL BIOLOGY

Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites

(2018) Kentaro Hanada   JOURNAL OF LIPID RESEARCH

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

(2018) James P Zewe et al.   eLife

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Protein kinase D1 and oxysterol-binding protein form a regulatory complex independent of phosphorylation

(2018) Asako Goto et al.   TRAFFIC

C24 Sphingolipids Govern the Transbilayer Asymmetry of Cholesterol and Lateral Organization of Model and Live-Cell Plasma Membranes

(2018) K.C. Courtney et al.   Cell Reports

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)

(2018) Huan Wang et al.   MOLECULAR CELL

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

(2018) Louise H. Wong et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

(2018) Jie Luo et al.   TRENDS IN BIOCHEMICAL SCIENCES

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

Speed Limits for Nonvesicular Intracellular Sterol Transport

(2017) Jeremy S. Dittman et al.   TRENDS IN BIOCHEMICAL SCIENCES

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

(2017) Rajesh Ghai et al.   Nature Communications

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome

(2016) Sarah E. Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An inducible ER–Golgi tether facilitates ceramide transport to alleviate lipotoxicity

(2016) Li-Ka Liu et al.   JOURNAL OF CELL BIOLOGY

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

(2016) Amrita Jain et al.   JOURNAL OF CELL SCIENCE

Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

(2016) Shu-Lin Liu et al.   Nature Chemical Biology

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

(2016) Antonella Chiapparino et al.   PROGRESS IN LIPID RESEARCH

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity

(2015) Marion Weber-Boyvat et al.   EXPERIMENTAL CELL RESEARCH

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions

(2015) Chi-Lun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Phosphoregulation of the Ceramide Transport Protein CERT at Serine 315 in the Interaction with VAMP-associated Protein (VAP) for Inter-organelle Trafficking of Ceramide in Mammalian Cells

(2014) Keigo Kumagai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

De Novo Mutations in Moderate or Severe Intellectual Disability

(2014) Fadi F. Hamdan et al.   PLoS Genetics

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

(2013) SoHui Kim et al.   EMBO REPORTS

Structure of Osh3 Reveals a Conserved Mode of Phosphoinositide Binding in Oxysterol-Binding Proteins

(2013) Junsen Tong et al.   STRUCTURE

Golgi Membrane Dynamics and Lipid Metabolism

(2012) Vytas A. Bankaitis et al.   CURRENT BIOLOGY

Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis

(2012) Asako Goto et al.   MOLECULAR BIOLOGY OF THE CELL

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Regulation of Oxysterol-binding Protein Golgi Localization through Protein Kinase D–mediated Phosphorylation

(2010) Sokha Nhek et al.   MOLECULAR BIOLOGY OF THE CELL

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

(2008) Diego Peretti et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol

(2008) Yvonne Lange et al.   PROGRESS IN LIPID RESEARCH

The VAP protein family: from cellular functions to motor neuron disease

(2008) Sima Lev et al.   TRENDS IN CELL BIOLOGY