Article
Endocrinology & Metabolism
Hamdy A. A. Aly
Summary: Diabetes induces testicular damage, partially through inducing mitochondria-mediated apoptosis and oxidative stress. Resveratrol administration improves diabetes-induced testicular dysfunction through its antioxidant and anti-apoptotic effects.
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Harpal S. Randeva, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Resveratrol, a polyphenol chemical found in many plant-based dietary products, has potential health benefits. After ingestion, it undergoes extensive metabolism, inhibits adipogenesis and fat accumulation, possesses anti-inflammatory effects, and may improve insulin sensitivity and inflammatory status. However, optimal dosage and benefits within the general population need further research.
Review
Biochemistry & Molecular Biology
Laura M. Mongioi, Sandro La Vignera, Rossella Cannarella, Laura Cimino, Michele Compagnone, Rosita A. Condorelli, Aldo E. Calogero
Summary: Obesity is a common disease with serious comorbidities, making its treatment clinically and socially significant. Resveratrol, as a therapeutic strategy against obesity, has garnered interest due to its beneficial effects such as antioxidant properties, cytoprotective abilities, and improvement of metabolic profile in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Andrology
Nese Basak Turkmen, Osman Ciftci, Asli Taslidere, Muhterem Aydin, Binay Can Eke
Summary: This study aimed to investigate the protective effects of Anastrozole and Resveratrol against reproductive damage induced by Pembrolizumab. The results showed that Anastrozole and Resveratrol could alleviate the reproductive damage caused by PEMB in rats.
Article
Biochemistry & Molecular Biology
Huixin Peng, Yanxin Huang, Guangji Wei, Yanfang Pang, Huixiong Yuan, Xiong Zou, Yu'an Xie, Wencheng Chen
Summary: Aluminum chloride (AlCl3) exposure leads to decreased levels of sex hormones and testicular damage in rats. Proteomics analysis revealed that differentially expressed proteins (DEPs) after AlCl3 exposure were primarily associated with various metabolic processes, sperm fibrous sheath, calcium-dependent protein binding, oxidative phosphorylation, and ribosomes. Western blot experiments confirmed the downregulation of sperm-related DEPs (AKAP4, ODF1, and OAZ3) and the upregulation of regulatory ribosome-associated protein (UBA52) and mitochondrial ribosomal protein (MRPL32). These findings provide insights into the mechanism of testicular toxicity caused by AlCl3 exposure.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Ya Zheng, Bin Mao, Qian Wang, Xin Duan, Meng-Yan Chen, Wei Shen, Chao Li, Yu-Feng Wang
Summary: Knockdown of ocn gene in Drosophila testes resulted in smaller testis without germ cells. Through proteomics sequencing, 606 proteins were identified as significantly changed in expression after ocn knockdown. The down-regulation of ocn disturbed key signaling pathways related to cell survival and differentiation.
Article
Endocrinology & Metabolism
Shuqiong Wang, Youwen Wei, Caiyan Hu, Fang Liu
Summary: Chronic hypoxia exposure exacerbates low testosterone production in obese male mice by influencing key proteins involved in steroid hormone biosynthesis, cholesterol biosynthesis, oxidative stress responses, and retinol metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yulong Ye, Chunyan Fang, Lanying Li, Dongna Liu, Yingchun Wang, Fan Huang, Xuejiao Gong, Yaqiong Xu, Yu Yao, Shanrong Ye, Dejian Feng, Fan Luo
Summary: This study evaluated the effects of the main amino acid theanine in tea on cyclophosphamide-induced testicular toxicity in male mice. The results showed that theanine could alleviate the damage to the testicles caused by cyclophosphamide and have impacts on multiple metabolic pathways and protein production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Guo-lin Xu, Xiao-lin Ye, Manoj Kumar Vashisth, Wen-zhen Zhao
Summary: This study aims to clarify the expression of PRDX2 in the testes of obese mice and lay a foundation for further exploration of its regulatory and protective effects on spermatogenesis. The results showed that PRDX2 expression was reduced in the testes of obese mice, and hydrogen peroxide and cholesterol had different regulatory effects on the expression of PRDX2 in Sertoli cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shanshan Tian, Yanfeng Zhao, Li Qian, Su Jiang, Yunping Tang, Tao Han
Summary: This study investigated the protective effect of DHA-PS on high-fat diet-induced jejunum injury. The results showed that DHA-PS reduced inflammation, alleviated oxidative stress, improved tight junction protein expression, repaired intestinal barrier damage, and modulated gut microbiota disorder. In conclusion, DHA-PS can alleviate high-fat diet-induced jejunum injury.
Article
Biochemistry & Molecular Biology
Zoheir B. Demmouche, Jacques J. Tremblay
Summary: Leydig cells produce testosterone, a hormone essential for male sex differentiation and spermatogenesis. LH stimulates testosterone production by activating various kinases and transcription factors through increasing cAMP levels. AMPK, activated by AMP, potently represses steroidogenesis. The study identifies global changes in protein and phosphoprotein levels during both the stimulatory and inhibitory phases of steroidogenesis, providing new insights into the finely tuned processes of adequate steroid hormone production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiao Chen, Yutong Wang, Jing Tian, Yurou Shao, Bo Zhu, Jigang Wang, Zichun Hua
Summary: Resveratrol inhibits A549 cell migration by binding to multiple target proteins to regulate cytoskeletal remodeling and suppress epithelial mesenchymal transition (EMT).
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Food Science & Technology
Nawel Benbouguerra, Ruth Hornedo-Ortega, Francois Garcia, Toni El Khawand, Cedric Saucier, Tristan Richard
Summary: Stilbenes are natural phenolic compounds synthesized by plants in response to stress. They are found in grape berries and wine, with potential anti-obesity effects. Optimized analytical methods are essential for accurate detection and quantification of stilbenes.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guadalupe L. Rodriguez-Gonzalez, Lilia Vargas-Hernandez, Luis A. Reyes-Castro, Carlos A. Ibanez, Claudia J. Bautista, Consuelo Lomas-Soria, Nozomi Itani, Guadalupe Estrada-Gutierrez, Aurora Espejel-Nunez, Arturo Flores-Pliego, Araceli Montoya-Estrada, Enrique Reyes-Munoz, Paul D. Taylor, Peter W. Nathanielsz, Elena Zambrano
Summary: Maternal obesity leads to oxidative stress and metabolic dysfunction. Supplementation of obese mothers with resveratrol improves maternal metabolic alterations and reduces oxidative stress in the placenta and maternal and fetal liver, with a sex-dependent effect.
Review
Biochemistry & Molecular Biology
Federica Barbagallo, Sandro La Vignera, Rossella Cannarella, Laura M. Mongioi, Vincenzo Garofalo, Claudia Leanza, Marta Marino, Aldo E. Calogero, Rosita A. Condorelli
Summary: Obesity is closely related to male reproductive dysfunction, and SIRTs may play a significant role in this relationship. SIRTs regulate energy balance, lipid balance, glucose metabolism, and adipogenesis, but most studies have been conducted in animal models with limited research on humans. Further investigation is needed to understand the impact of obesity on male fertility and explore strategies to improve reproductive function in overweight/obese individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zheng-mei Lv, Qi Wang, Yuan-hua Chen, Sheng-hua Wang, Dao-qi Huang
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2015)
Article
Andrology
Chao Chen, Meng-yu Ling, Fan-hong Lin, Ling Xu, Zheng Mei Lv
Article
Biochemistry & Molecular Biology
Ping Wang, Mengyu Lin, Chao Chen, Zheng-mei Lv
Summary: This study found that resveratrol (RSV) has positive effects on steroidogenesis and mitochondrial function by stimulating autophagy and exerting antioxidant activities. These findings suggest that RSV is protective against obesity-related Leydig cell impairment.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Ping Wang, Shoubing Zhang, Shuai Lin, Zhengmei Lv
Summary: This study found that melatonin can improve steroidogenic dysfunction caused by diabetes, enhance cell autophagy and mitochondrial function, and alleviate oxidative stress. These findings are important for understanding the mechanism of action of melatonin in the treatment of diabetes-related complications.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Andrology
Juan Li, Fan-hong Lin, Xiao-mei Zhu, Zheng-mei Lv