Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT

Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53‑dependent pathway: Integrated bioinformatics analysis and experimental validation

(2020) Yameng Fan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CRISPR Approaches to Small Molecule Target Identification

(2018) Marco Jost et al.   ACS Chemical Biology

FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway

(2018) Lin Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-α and NADPH oxidase in lung epithelial A549 cells

(2018) Hung-Te Hsu et al.   BMC Complementary and Alternative Medicine

Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression

(2018) Xiao Chen et al.   Theranostics

Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses

(2017) Liwei He et al.   JOURNAL OF SURGICAL RESEARCH

ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+/RhoA pathway

(2017) Shuai Zhu et al.   Cell Death & Disease

Selective Cell Penetrating Peptide-Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo

(2017) Weijing Yang et al.   Advanced Healthcare Materials

Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression

(2017) Xiao Chen et al.   Scientific Reports

The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells

(2016) Song Hu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells

(2016) Shiyan Gu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

RhoA/ROCK Signaling Regulates TGFβ-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through MRTF-A

(2016) Anna Korol et al.   MOLECULAR MEDICINE

Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells

(2016) WEI SHI et al.   Molecular Medicine Reports

Target identification of natural and traditional medicines with quantitative chemical proteomics approaches

(2016) Jigang Wang et al.   PHARMACOLOGY & THERAPEUTICS

Target identification with quantitative activity based protein profiling (ABPP)

(2016) Xiao Chen et al.   PROTEOMICS

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line

(2016) Jigang Wang et al.   Scientific Reports

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

(2015) Beshay N.M. Zordoky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression

(2015) Qing Ji et al.   BMC CANCER

Resveratrol inhibits ovarian tumor growth in an in vivo mouse model

(2015) Lijun Tan et al.   CANCER

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

(2015) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Resveratrol: A potential challenger against gastric cancer

(2015) Aida Zulueta   WORLD JOURNAL OF GASTROENTEROLOGY

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Resveratrol Synergistically Triggers Apoptotic Cell Death with Arsenic Trioxide via Oxidative Stress in Human Lung Adenocarcinoma A549 Cells

(2014) Shiyan Gu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB

(2014) Soheil Zorofchian Moghadamtousi et al.   BMC Complementary and Alternative Medicine

A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

(2014) Xiamin Cheng et al.   CHEMICAL COMMUNICATIONS

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis

(2014) Jigang Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells

(2014) LONG YUAN et al.   Molecular Medicine Reports

Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence

(2014) Sarah Crawford   Therapeutic Advances in Medical Oncology

Autophagic cell death induced by resveratrol depends on the Ca2+/AMPK/mTOR pathway in A549 cells

(2013) Jun Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Venom present in sea anemone (Heteractis magnifica) induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-mediated pathway

(2013) Mahnaz Ramezanpour et al.   BIOTECHNOLOGY LETTERS

Resveratrol Inhibits the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells Via Suppression of the PI-3K/Akt/NF-κB Pathway

(2013) Wei Li et al.   CURRENT MEDICINAL CHEMISTRY

Regulation of Crosstalk between Epithelial to Mesenchymal Transition Molecules and MMP-9 Mediates the Antimetastatic Activity of Anethole in DU145 Prostate Cancer Cells

(2013) ByungChul Ha et al.   JOURNAL OF NATURAL PRODUCTS

A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis

(2013) Lina Sun et al.   JNCI-Journal of the National Cancer Institute

miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts

(2013) Loredana Pellegrino et al.   NUCLEIC ACIDS RESEARCH

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis

(2012) Heyong Wang et al.   TOXICOLOGY

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells

(2011) Seunghee Bae et al.   MOLECULES AND CELLS

Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition

(2011) Sharmila Shankar et al.   PLoS One

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis

(2010) Sílvia Cufí et al.   CELL CYCLE

Resveratrol Oligomers fromVatica albiramis

(2010) Naohito Abe et al.   JOURNAL OF NATURAL PRODUCTS

Doxorubicin in Combination with a Small TGFβ Inhibitor: A Potential Novel Therapy for Metastatic Breast Cancer in Mouse Models

(2010) Abhik Bandyopadhyay et al.   PLoS One

Revealing promiscuous drug–target interactions by chemical proteomics

(2009) Marcus Bantscheff et al.   DRUG DISCOVERY TODAY

Resveratrol bioavailability and toxicity in humans

(2009) Charles-Henry Cottart et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivo

(2009) Elena Kardash et al.   NATURE CELL BIOLOGY

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells⊥

(2008) Khalid A. El Sayed et al.   JOURNAL OF NATURAL PRODUCTS

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY