Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications

Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients

(2019) Sarina Levy-Mendelovich et al.   THROMBOSIS AND HAEMOSTASIS

Role of Platelet Transfusion in the Reversal of Anti-Platelet Therapy

(2019) Srikanth Nagalla et al.   TRANSFUSION MEDICINE REVIEWS

Interrelationships between structure and function during the hemostatic response to injury

(2019) Maurizio Tomaiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RASGRP2 gene variations associated with platelet dysfunction and bleeding

(2019) Verónica Palma-Barqueros et al.   PLATELETS

Hereditary platelet function disorder from RASGRP2 gene mutations encoding CalDAG-GEFI identified by whole exome sequencing in a Korean woman with severe bleeding

(2019) Jae Won Yun et al.   HAEMATOLOGICA

Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update

(2018) Charles A. Schiffer et al.   JOURNAL OF CLINICAL ONCOLOGY

Preoperative platelet transfusions to reverse antiplatelet therapy for urgent non-cardiac surgery: an observational cohort study

(2018) M. Baschin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A microengineered vascularized bleeding model that integrates the principal components of hemostasis

(2018) Yumiko Sakurai et al.   Nature Communications

How we treat the platelet glycoprotein defects; Glanzmann thrombasthenia and Bernard Soulier syndrome in children and adults

(2018) John D. Grainger et al.   BRITISH JOURNAL OF HAEMATOLOGY

In vivo viability of extended 4°C-stored autologous apheresis platelets

(2018) Moritz Stolla et al.   TRANSFUSION

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface

(2018) Dmitry Y. Nechipurenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bleeding risk of surgery and its prevention in patients with inherited platelet disorders

(2017) Sara Orsini et al.   HAEMATOLOGICA

Peripartum bleeding management in a patient with CalDAG-GEFI deficiency

(2017) M. Canault et al.   HAEMOPHILIA

Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature

(2017) J. D. Welsh et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia

(2017) Alan T. Nurden et al.   PLATELETS

Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis

(2017) Teresa Sevivas et al.   PLATELETS

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)

(2017) Emilse Bermejo et al.   PLATELETS

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

(2017) Liang Zhu et al.   Nature Communications

Bleeding risk of surgery and its prevention in patients with inherited platelet disorders

(2017) Sara Orsini et al.   HAEMATOLOGICA

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on HemostasisHighlights

(2016) Raymond Piatt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

(2016) M. L. Lozano et al.   BLOOD

Human CalDAG-GEFI deficiency increases bleeding and delays  IIb 3 activation

(2016) H. Kato et al.   BLOOD

Assessment of human platelet survival in the NOD/SCID mouse model: technical considerations

(2016) Julia Fuhrmann et al.   TRANSFUSION

Platelet Transfusion: A Clinical Practice Guideline From the AABB

(2015) Richard M. Kaufman et al.   ANNALS OF INTERNAL MEDICINE

Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

(2015) Elisa Civaschi et al.   BRITISH JOURNAL OF HAEMATOLOGY

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

RAP1-GTPase signaling and platelet function

(2015) Lucia Stefanini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition

(2015) T. M. Getz et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Spectrum of the Mutations in Bernard-Soulier Syndrome

(2014) Anna Savoia et al.   HUMAN MUTATION

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional and molecular characterization of inherited platelet disorders in the Iberian Peninsula: results from a collaborative study

(2014) Isabel Sánchez-Guiu et al.   Orphanet Journal of Rare Diseases

Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice

(2013) M. Morowski et al.   BLOOD

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary

(2012) Patrick T. O'Gara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis

(2011) F. AHMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

What To Do When You Suspect an Inherited Platelet Disorder

(2011) M. P. Lambert   Hematology-American Society of Hematology Education Program

Platelet receptor signaling in thrombus formation

(2010) David Stegner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Survival and function of transfused platelets. Studies in two patients with congenital deficiencies of platelet membrane glycoproteins

(2009) Jesús M. Cesar et al.   PLATELETS

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD