Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

(2019) Kimberly J Dunham-Snary et al.   CIRCULATION RESEARCH

Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization

(2018) Ignacio Arias-Mayenco et al.   Cell Metabolism

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

(2018) Oleg Pak et al.   EUROPEAN RESPIRATORY JOURNAL

PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies

(2018) James W. Fielding et al.   JOURNAL OF PHYSIOLOGY-LONDON

Correction: HIF-2α is essential for carotid body development and function

(2018) David Macias et al.   eLife

Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells

(2017) Lin Gao et al.   JOURNAL OF PHYSIOLOGY-LONDON

A sensible approach to making sense of oxygen sensing

(2017) Colin A. Nurse   JOURNAL OF PHYSIOLOGY-LONDON

Acute oxygen sensing by the carotid body: a rattlebag of molecular mechanisms

(2017) Ryan J. Rakoczy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of cystathionine-γ-lyase in hypoxia-induced changes in TASK activity, intracellular [Ca 2+ ] and ventilation in mice

(2017) Jiaju Wang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Regulation of Mammalian 13-Subunit Cytochrome c Oxidase and Binding of other Proteins: Role of NDUFA4

(2017) Bernhard Kadenbach   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lifetime imaging of GFP at CoxVIIIa reports respiratory supercomplex assembly in live cells

(2017) Bettina Rieger et al.   Scientific Reports

Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia

(2016) José López-Barneo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea

(2016) Amira D. Mahmoud et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Structure of Mammalian Respiratory Supercomplex I 1 III 2 IV 1

(2016) Meng Wu et al.   CELL

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE

(2016) Zhiyu Dai et al.   CIRCULATION

Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion

(2016) Patricia Ortega-Sáenz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Single cell transcriptome analysis of mouse carotid body glomus cells

(2016) Ting Zhou et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice

(2016) Pinelopi P. Kapitsinou et al.   MOLECULAR AND CELLULAR BIOLOGY

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

HIF2α–arginase axis is essential for the development of pulmonary hypertension

(2016) Andrew S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role Of Hif2α Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation

(2016) Mar Torres-Capelli et al.   Scientific Reports

Acute Oxygen Sensing—Inching Ever Closer to an Elusive Mechanism

(2015) Chris Peers   Cell Metabolism

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

(2015) Emma J. Hodson et al.   JOURNAL OF PHYSIOLOGY-LONDON

The subunit composition and function of mammalian cytochrome c oxidase

(2015) Bernhard Kadenbach et al.   MITOCHONDRION

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

(2014) D. Macias et al.   EMBO Molecular Medicine

Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells

(2013) Keith J. Buckler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

(2013) Siddhesh Aras et al.   NUCLEIC ACIDS RESEARCH

Mutual antagonism between hypoxia-inducible factors 1  and 2  regulates oxygen sensing and cardio-respiratory homeostasis

(2013) G. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain

(2012) Eduardo Balsa et al.   Cell Metabolism

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

(2012) Maik Hüttemann et al.   FASEB JOURNAL

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Hypoxia-inducible factor 2  (HIF-2 ) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

(2011) Y.-J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

Carotid body chemosensory responses in mice deficient of TASK channels

(2010) Patricia Ortega-Sáenz et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and Analysis

(2010) Luc J. Teppema et al.   PHYSIOLOGICAL REVIEWS

Regulation of Oxygen Sensitivity in Adrenal Chromaffin Cells

(2009) Colin A. Nurse et al.   Annals of the New York Academy of Sciences

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH