Role of Microenvironment in Resistance to Therapy in AML

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF- B mediates chemoresistance

(2014) R. Jacamo et al.   BLOOD

Advances in understanding the leukaemia microenvironment

(2014) Yoko Tabe et al.   BRITISH JOURNAL OF HAEMATOLOGY

SnapShot: The Hematopoietic Stem Cell Niche

(2014) Youmna Kfoury et al.   CELL

Rewiring the Niche: Sympathetic Neuropathy Drives Malignant Niche Transformation

(2014) Trevor Price et al.   Cell Stem Cell

Disease Progression in Myelodysplastic Syndromes: Do Mesenchymal Cells Pave the Way?

(2014) Marc H.G.P. Raaijmakers   Cell Stem Cell

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches

(2013) Karin Williams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Acute myeloid leukaemia in adults

(2013) Felicetto Ferrara et al.   LANCET

Dynamic Chemotherapy-Induced Upregulation of CXCR4 Expression: A Mechanism of Therapeutic Resistance in Pediatric AML

(2013) E. A. R. Sison et al.   MOLECULAR CANCER RESEARCH

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

(2013) Kimberly A Hartwell et al.   Nature Chemical Biology

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

(2013) Daniel Lucas et al.   NATURE MEDICINE

TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment

(2013) Yoko Tabe et al.   PLoS One

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies

(2012) M. R. Kuhne et al.   CLINICAL CANCER RESEARCH

Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): Inhibition of osteoclast growth and differentiation

(2012) H.C. Schröder et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

(2012) Anna Mansour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

The vascular niche: home for normal and malignant hematopoietic stem cells

(2011) P L Doan et al.   LEUKEMIA

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo

(2010) S. Lymperi et al.   BLOOD

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

(2010) I. G. Winkler et al.   BLOOD

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

(2009) M. J. Christopher et al.   BLOOD

Therapeutic targeting of microenvironmental interactions in leukemia: Mechanisms and approaches

(2009) Marina Konopleva et al.   DRUG RESISTANCE UPDATES

 4 1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells

(2008) J. Redondo-Munoz et al.   BLOOD

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

(2008) M. Fiegl et al.   BLOOD

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

(2008) B. Nervi et al.   BLOOD

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE