Translating preclinical models to humans

Computational translation of genomic responses from experimental model systems to humans

(2019) Douglas K. Brubaker et al.   PLoS Computational Biology

Conservation, acquisition, and functional impact of sex-biased gene expression in mammals

(2019) Sahin Naqvi et al.   SCIENCE

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

(2019) Douglas K. Brubaker et al.   Cell Systems

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

(2018) Louis R. Joslyn et al.   Frontiers in Microbiology

An integrative tissue-network approach to identify and test human disease genes

(2018) Victoria Yao et al.   NATURE BIOTECHNOLOGY

Found In Translation: a machine learning model for mouse-to-human inference

(2018) Rachelly Normand et al.   NATURE METHODS

Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions

(2017) Edik M. Blais et al.   Nature Communications

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

(2014) Kahn Rhrissorrakrai et al.   BIOINFORMATICS

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PhenoDigm: analyzing curated annotations to associate animal models with human diseases

(2013) D. Smedley et al.   Database-The Journal of Biological Databases and Curation

When orthologs diverge between human and mouse

(2011) W. H. Gharib et al.   BRIEFINGS IN BIOINFORMATICS

Accurate Quantification of Functional Analogy among Close Homologs

(2011) Maria D. Chikina et al.   PLoS Computational Biology