Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme

PDE10A mutation in two sisters with a hyperkinetic movement disorder - Response to levodopa

(2019) C. Knopp et al.   PARKINSONISM & RELATED DISORDERS

PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders

(2019) Ellanor L. Whiteley et al.   CELLULAR SIGNALLING

Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

(2018) Tianming Qiu et al.   Cell Death & Disease

PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology

(2018) Flavia Niccolini et al.   MOVEMENT DISORDERS

Ubiquitin signaling and autophagy

(2017) Paolo Grumati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A PDE10A de novo mutation causes childhood-onset chorea with diurnal fluctuations

(2017) Silvia Esposito et al.   MOVEMENT DISORDERS

De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions

(2016) Niccolò E. Mencacci et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy

(2016) Christine P. Diggle et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The effects of proteasomal inhibition on synaptic proteostasis

(2016) Vicky Hakim et al.   EMBO JOURNAL

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers

(2016) Heather Wilson et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging

(2016) David S. Russell et al.   NEUROLOGY

Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway

(2016) Jie Bai et al.   Scientific Reports

Caveolin-1 is an aggresome-inducing protein

(2016) Ajit Tiwari et al.   Scientific Reports

Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease

(2015) Flavia Niccolini et al.   BRAIN

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease

(2015) Flavia Niccolini et al.   BRAIN

Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum

(2015) Corina Russwurm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13S-Acyltransferases

(2015) Kimon Lemonidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in brain phosphodiesterase 10A levels in neurodegenerative basal ganglia disorders

(2015) Heather Wood   Nature Reviews Neurology

Implications of aromatic-aromatic interactions: From protein structures to peptide models

(2015) Kamlesh Madhusudan Makwana et al.   PROTEIN SCIENCE

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

(2014) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

(2014) D J P Henderson et al.   BRITISH JOURNAL OF CANCER

Neurodegenerative disorders: Dysregulation of a carefully maintained balance?

(2014) Chrisna Swart et al.   EXPERIMENTAL GERONTOLOGY

Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels

(2014) Pim W. J. M. Frederix et al.   Nature Chemistry

Regulated protein turnover: snapshots of the proteasome in action

(2014) Sucharita Bhattacharyya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice

(2014) Maarten Ooms et al.   NEUROBIOLOGY OF AGING

When less becomes more: Optimization of protein expression in HEK293–EBNA1 cells using plasmid titration – A case study for NLRs

(2014) Els F. Halff et al.   PROTEIN EXPRESSION AND PURIFICATION

The Phosphodiesterase 10 Positron Emission Tomography Tracer, [18F]MNI-659, as a Novel Biomarker for Early Huntington Disease

(2014) David S. Russell et al.   JAMA Neurology

Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia

(2013) E. I. Charych et al.   JOURNAL OF NEUROSCIENCE

PET imaging shows loss of striatal PDE10A in patients with Huntington disease

(2013) R. Ahmad et al.   NEUROLOGY

Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6)

(2012) Suzanne L. Matte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease

(2012) J.-T. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulated protein aggregation: stress granules and neurodegeneration

(2012) Benjamin Wolozin   Molecular Neurodegeneration

DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells

(2011) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential vulnerability of neurons in Huntington’s disease: the role of cell type-specific features

(2010) Ina Han et al.   JOURNAL OF NEUROCHEMISTRY

Analysis of proteome dynamics in the mouse brain

(2010) J. C. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

Early endosomes and endosomal coatomer are required for autophagy

(2009) Minoo Razi et al.   JOURNAL OF CELL BIOLOGY

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications

(2008) L. Chin et al.   CURRENT MEDICINAL CHEMISTRY

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP

(2008) Noriko Handa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY