The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation

(2017) V N Thiel et al.   LEUKEMIA

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

(2017) Fengbiao Zhou et al.   NATURE CELL BIOLOGY

Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts

(2017) Marten Hansen et al.   Stem Cell Research

Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential

(2017) Hany E. Marei et al.   Scientific Reports

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs

(2016) Amit Mandoli et al.   Cell Reports

AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells

(2016) Marco Saia et al.   Scientific Reports

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia

(2015) Min Ye et al.   Cell Stem Cell

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors

(2015) Christian Schmidl et al.   NATURE METHODS

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

(2014) J. Goveia et al.   EMBO Molecular Medicine

AML1-ETO triggers epigenetic activation of early growth response gene l, inducing apoptosis in t(8;21) acute myeloid leukemia

(2013) Lin Fu et al.   FEBS Journal

Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis

(2013) T. Morishima et al.   HAEMATOLOGICA

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

(2013) Xiao-Jian Sun et al.   NATURE

ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia

(2012) J. H. A. Martens et al.   BLOOD

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs

(2012) A Maiques-Diaz et al.   LEUKEMIA

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

(2012) Megan A. Hatlen et al.   Frontiers of Medicine

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein

(2011) B. Steffen et al.   BLOOD

A Novel Serum-Free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells via Mesodermal Progenitors

(2011) Akira Niwa et al.   PLoS One

The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation

(2011) L. Wang et al.   SCIENCE

Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies

(2011) Angelica Trujillo et al.   Journal of Oncology

Identification of AML1-ETO modulators by chemical genomics

(2009) S. M. Corsello et al.   BLOOD

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Deregulation of Signaling Pathways in Acute Myeloid Leukemia

(2008) Claudia Scholl et al.   SEMINARS IN ONCOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY