Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders

(2016) Mark Y. Chiang et al.   CURRENT OPINION IN HEMATOLOGY

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes

(2016) Franz Oswald et al.   NUCLEIC ACIDS RESEARCH

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia

(2012) J. H. A. Martens et al.   BLOOD

Contribution of an Aged Microenvironment to Aging-Associated Myeloproliferative Disease

(2012) Virag Vas et al.   PLoS One

Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

(2011) Marloes R. Tijssen et al.   DEVELOPMENTAL CELL

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

(2011) Kentson Lam   Frontiers in Bioscience-Landmark

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J

(2010) Stephan Armin Wacker et al.   EMBO JOURNAL

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

(2010) M. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CBF  is critical for AML1-ETO and TEL-AML1 activity

(2009) L. Roudaia et al.   BLOOD

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2

(2009) B Jiao et al.   LEUKEMIA

Transforming activity of AML1-ETO is independent of CBFβ and ETO interaction but requires formation of homo-oligomeric complexes

(2009) Colin Kwok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis

(2008) M. Yan et al.   BLOOD

t(8;21)(q22;q22) fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression

(2008) A. J. Okumura et al.   BLOOD

ETO, but Not Leukemogenic Fusion Protein AML1/ETO, Augments RBP-J /SHARP-Mediated Repression of Notch Target Genes

(2008) D. Salat et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis

(2008) E.-Y. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets

(2008) Alessandro Gardini et al.   PLoS Genetics