Journal
AGING-US
Volume 7, Issue 6, Pages 383-388Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100759
Keywords
glucose; C. elegans; sex specificity; mobility; healthspan
Categories
Funding
- Holy Cross Biology Department
- Robert L. Ardizzone Fund for Junior Faculty Excellence
- Batchelor-Ford Faculty Fellowship
- BD Corporation Summer Fellowships
- Holy Cross Summer Research Fellowship
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Diet and sex are important determinants of lifespan. In humans, high sugar diets, obesity, and type 2 diabetes correlate with decreased lifespan, and females generally live longer than males. The nematode Caenorhabditis elegans is a classical model for aging studies, and has also proven useful for characterizing the response to high-glucose diets. However, studies on male animals are lacking. We found a surprising dichotomy: glucose regulates lifespan and aging in a sex-specific manner, with beneficial effects on males compared to toxic effects on hermaphrodites. High-glucose diet resulted in greater mobility with age for males, along with a modest increase in median lifespan. In contrast, high-glucose diets decrease both lifespan and mobility for hermaphrodites. Understanding sex-specific responses to high-glucose diets will be important for determining which evolutionarily conserved glucose-responsive pathways that regulate aging are universal and which are likely to be cell-type or sex-specific.
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