The role of motile cilia in the development and physiology of the nervous system

Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development

(2019) Emilie W. Olstad et al.   CURRENT BIOLOGY

Development of a CFD model for mucociliary clearance in the nasal cavity

(2019) Yidan Shang et al.   JOURNAL OF BIOMECHANICS

Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members

(2019) Gonzalo Ortiz-Álvarez et al.   NEURON

Developmental Biology: Go with the Flow to Keep the Body Straight

(2019) Daniel T. Grimes   CURRENT BIOLOGY

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor

(2019) Stephanie A. Redmond et al.   Cell Reports

Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons

(2019) Laura Desban et al.   PLOS BIOLOGY

The cilium as a force sensor−myth versus reality

(2019) Rita R. Ferreira et al.   JOURNAL OF CELL SCIENCE

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

(2019) Karol Kaiser et al.   Nature Communications

Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus

(2019) Priya Date et al.   Scientific Reports

A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP

(2019) Eric D Larson et al.   CHEMICAL SENSES

Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function

(2018) Prajay T. Shah et al.   CELL

Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone

(2018) Emily E. Noble et al.   Cell Metabolism

Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner

(2018) David Petrik et al.   Cell Stem Cell

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice

(2018) Zakia Abdelhamed et al.   DEVELOPMENT

Radial spoke proteins regulate otolith formation during early zebrafish development

(2018) Xiao Han et al.   FASEB JOURNAL

The spinal ependymal zone as a source of endogenous repair cells across vertebrates

(2018) Catherina G. Becker et al.   PROGRESS IN NEUROBIOLOGY

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

(2018) Andreas Bjorefeldt et al.   Frontiers in Neural Circuits

A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5

(2018) Lisanne Martine van Leeuwen et al.   Biology Open

The subcommissural organ and the Reissner fiber: old friends revisited

(2018) Rosa I. Muñoz et al.   CELL AND TISSUE RESEARCH

The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis

(2018) Yasmine Cantaut-Belarif et al.   CURRENT BIOLOGY

Characterization of the ventricular-subventricular stem cell niche during human brain development

(2018) Amanda M. Coletti et al.   DEVELOPMENT

Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

(2018) Alán Alpár et al.   EMBO JOURNAL

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

(2018) Jenna R. Sternberg et al.   Nature Communications

Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis

(2018) Xiaoli Zhang et al.   NATURE GENETICS

Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development

(2018) Mia J. Konjikusic et al.   PLoS Genetics

Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance

(2018) Luis A Bezares-Calderón et al.   eLife

Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis

(2018) J. L. M. Van Gennip et al.   Science Advances

Light on a sensory interface linking the cerebrospinal fluid to motor circuits in vertebrates

(2017) Lydia Djenoune et al.   JOURNAL OF NEUROGENETICS

The development and functions of multiciliated epithelia

(2017) Nathalie Spassky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought

(2017) Curtis W. Boswell et al.   TRENDS IN GENETICS

Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories

(2017) Zaman Mirzadeh et al.   Nature Communications

Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish

(2017) Ana Ribeiro et al.   Open Biology

The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes

(2017) Lydia Djenoune et al.   Scientific Reports

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

(2016) Matthew J. Simon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

(2016) Violeta Silva-Vargas et al.   Cell Stem Cell

The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord

(2016) Yanina L. Petracca et al.   DEVELOPMENT

Characterization of multiciliated ependymal cells that emerge in the neurogenic niche of the aged zebrafish brain

(2016) Takashi Ogino et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A single polycystic kidney disease 2-like 1 channel opening acts as a spike generator in cerebrospinal fluid-contacting neurons of adult mouse brainstem

(2016) Adeline Orts-Del'Immagine et al.   NEUROPHARMACOLOGY

Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature

(2016) D. T. Grimes et al.   SCIENCE

Cilia-based flow network in the brain ventricles

(2016) R. Faubel et al.   SCIENCE

Cilia and Mucociliary Clearance

(2016) Ximena M. Bustamante-Marin et al.   Cold Spring Harbor Perspectives in Biology

Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3

(2016) Elham Jalalvand et al.   Nature Communications

CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

(2016) Urs Lucas Böhm et al.   Nature Communications

Head movement, an important contributor to human cerebrospinal fluid circulation

(2016) Qiang Xu et al.   Scientific Reports

Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure

(2015) Kevin F. Chau et al.   DEVELOPMENTAL CELL

Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

(2015) Catherina G. Becker et al.   DEVELOPMENTAL CELL

Gene Expression by Mouse Inner Ear Hair Cells during Development

(2015) D. I. Scheffer et al.   JOURNAL OF NEUROSCIENCE

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium

(2015) S. Ohata et al.   JOURNAL OF NEUROSCIENCE

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production

(2015) M. P. Lun et al.   JOURNAL OF NEUROSCIENCE

Development and functions of the choroid plexus–cerebrospinal fluid system

(2015) Melody P. Lun et al.   NATURE REVIEWS NEUROSCIENCE

RFX transcription factors are essential for hearing in mice

(2015) Ran Elkon et al.   Nature Communications

Odorant-Binding Proteins and Xenobiotic Metabolizing Enzymes: Implications in Olfactory Perireceptor Events

(2014) Jean-Marie Heydel et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

A Structural Basis for How Motile Cilia Beat

(2014) Peter Satir et al.   BIOSCIENCE

Systematic discovery of novel ciliary genes through functional genomics in the zebrafish

(2014) S. P. Choksi et al.   DEVELOPMENT

Kinesin family member 6 (kif6) is necessary for spine development in zebrafish

(2014) Jillian G. Buchan et al.   DEVELOPMENTAL DYNAMICS

Laterally projecting cerebrospinal fluid-contacting cells in the lamprey spinal cord are of two distinct types

(2014) Elham Jalalvand et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

(2014) B. Siyahhan et al.   Journal of the Royal Society Interface

Integrating the active process of hair cells with cochlear function

(2014) A. J. Hudspeth   NATURE REVIEWS NEUROSCIENCE

Endothelial NT-3 Delivered by Vasculature and CSF Promotes Quiescence of Subependymal Neural Stem Cells through Nitric Oxide Induction

(2014) Ana C. Delgado et al.   NEURON

Sp8 regulates inner ear development

(2014) H. A. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary cilia are required in a unique subpopulation of neural progenitors

(2014) C. K. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease

(2014) Madeline Hayes et al.   Nature Communications

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

(2014) Corey L. Williams et al.   Nature Communications

Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates

(2014) Lydia Djenoune et al.   Frontiers in Neuroanatomy

Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia

(2013) Daniel J. Moore et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Adult Macaque Spinal Cord Central Canal Zone Contains Proliferative Cells And Closely Resembles The Human

(2013) Clara Alfaro-Cervello et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Riding the wave of ependymal cilia: Genetic susceptibility to hydrocephalus in primary ciliary dyskinesia

(2013) Lance Lee   JOURNAL OF NEUROSCIENCE RESEARCH

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

(2013) Grégory Conductier et al.   NATURE NEUROSCIENCE

The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone

(2013) Anna Bylander et al.   Reproductive Biology and Endocrinology

The role of ear stone size in hair cell acoustic sensory transduction

(2013) Maya Inoue et al.   Scientific Reports

The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle

(2012) G. A. Stooke-Vaughan et al.   DEVELOPMENT

The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain

(2012) Benjamin W. Lindsey et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Biciliated ependymal cell proliferation contributes to spinal cord growth

(2012) Clara Alfaro-Cervello et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Heparan-Dependent Herpesvirus Targets the Olfactory Neuroepithelium for Host Entry

(2012) Ricardo Milho et al.   PLoS Pathogens

Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear

(2011) X. Yu et al.   DEVELOPMENT

Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors

(2011) V. Kroehne et al.   DEVELOPMENT

Mechanistic Basis of Otolith Formation during Teleost Inner Ear Development

(2011) David Wu et al.   DEVELOPMENTAL CELL

Adult neurogenesis and brain regeneration in zebrafish

(2011) Caghan Kizil et al.   Developmental Neurobiology

Precise olfactory responses tile the sniff cycle

(2011) Roman Shusterman et al.   NATURE NEUROSCIENCE

The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

(2011) Maria K. Lehtinen et al.   NEURON

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

(2010) C. Cruz et al.   DEVELOPMENT

Ependymal cells: biology and pathology

(2009) Marc R. Del Bigio   ACTA NEUROPATHOLOGICA

Totally tubular: the mystery behind function and origin of the brain ventricular system

(2009) Laura Anne Lowery et al.   BIOESSAYS

Olfactory Cilia: Linking Sensory Cilia Function and Human Disease

(2009) P. M. Jenkins et al.   CHEMICAL SENSES

FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain

(2009) B. V. Jacquet et al.   DEVELOPMENT

A zebrafish gene trap line expresses GFP recapturing expression pattern of foxj1b

(2009) Tian Tian et al.   Journal of Genetics and Genomics

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

(2009) Marie Carlén et al.   NATURE NEUROSCIENCE

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Multiple Primary Cilia Modulate the Fluid Transcytosis in Choroid Plexus Epithelium

(2009) Keishi Narita et al.   TRAFFIC

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

(2008) Richard L. Doty   ANNALS OF NEUROLOGY

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos

(2008) Emil Aamar et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Hydrodynamic aspects of fish olfaction

(2008) J. P.L Cox   Journal of the Royal Society Interface

The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear

(2008) Jessica R. Colantonio et al.   NATURE

Foxj1 transcription factors are master regulators of the motile ciliogenic program

(2008) Xianwen Yu et al.   NATURE GENETICS

The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos

(2008) Jennifer L Stubbs et al.   NATURE GENETICS

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY