Homeodomain‐interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer

MicroRNA-222-3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation, invasion, and inhibits apoptosis in gastric cancer

(2018) Xiaoyan Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-197 induces epithelial–mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma

(2018) Nan Zhang et al.   JOURNAL OF GENETICS

HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death

(2018) Yulei Shang et al.   JOURNAL OF NEUROSCIENCE

Challenges in diagnosis of pancreatic cancer

(2018) Lulu Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Targeting the MAPK Pathway in RAS Mutant Cancers

(2018) Sarah G. Hymowitz et al.   Cold Spring Harbor Perspectives in Medicine

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

(2017) L Torrente et al.   ONCOGENE

Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1

(2016) E.-J. Ann et al.   CANCER RESEARCH

Concepts to Target MYC in Pancreatic Cancer

(2016) M. Wirth et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function

(2015) N. V. Rajeshkumar et al.   CANCER RESEARCH

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer

(2015) Shunrong Ji et al.   CELL RESEARCH

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies

(2015) E Hessmann et al.   ONCOGENE

Integration of stress signals by homeodomain interacting protein kinases

(2014) Michael Lienhard Schmitz et al.   BIOLOGICAL CHEMISTRY

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Downregulation of HIPK2 Increases Resistance of Bladder Cancer Cell to Cisplatin by Regulating Wip1

(2014) Jun Lin et al.   PLoS One

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage

(2013) Laureano de la Vega et al.   NUCLEIC ACIDS RESEARCH

Notch signaling in pancreatic cancer: oncogene or tumor suppressor?

(2013) Jacqueline L. Avila et al.   TRENDS IN MOLECULAR MEDICINE

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

(2012) Thomas G. Hofmann et al.   BIOESSAYS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Conceptual Framework for Cutting the Pancreatic Cancer Fuel Supply

(2012) A. Le et al.   CLINICAL CANCER RESEARCH

Targeting Cancer Metabolism

(2012) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Homeodomain-Interacting Protein Kinase Regulates Hippo Pathway-Dependent Tissue Growth

(2012) Carole L.C. Poon et al.   CURRENT BIOLOGY

Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice

(2012) N. Shojima et al.   DIABETOLOGIA

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Energy metabolism and proliferation in pancreatic carcinogenesis

(2012) Ivonne Regel et al.   LANGENBECKS ARCHIVES OF SURGERY

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage

(2011) C Lazzari et al.   ONCOGENE

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions

(2010) Stefanie Ritterhoff et al.   EMBO JOURNAL

HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage

(2009) S. Iacovelli et al.   CELL PROLIFERATION

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

(2009) Lavinia Nardinocchi et al.   Molecular Cancer

Transcriptional regulation of hypoxia-inducible factor 1α by HIPK2 suggests a novel mechanism to restrain tumor growth

(2008) Lavinia Nardinocchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis

(2008) X Li et al.   CELL DEATH AND DIFFERENTIATION

Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho

(2008) Wendy Lee et al.   DEVELOPMENTAL BIOLOGY

A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition

(2008) A P Smith et al.   ONCOGENE