Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

The 5-HT1B receptor - a potential target for antidepressant treatment

(2018) Mikael Tiger et al.   PSYCHOPHARMACOLOGY

Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties

(2018) Huan Bao et al.   NATURE

Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes

(2017) Zack Zurawski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina

(2017) Matthew J. Van Hook et al.   JOURNAL OF NEUROSCIENCE

What do monoamines do in pain modulation?

(2016) Kirsty Bannister et al.   Current Opinion in Supportive and Palliative Care

Positively Charged Amino Acids at the SNAP-25 C Terminus Determine Fusion Rates, Fusion Pore Properties, and Energetics of Tight SNARE Complex Zippering

(2015) Q. Fang et al.   JOURNAL OF NEUROSCIENCE

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice

(2015) Yann S. Mineur et al.   PSYCHOPHARMACOLOGY

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior

(2015) Z T Freeman et al.   Translational Psychiatry

The α2-adrenergic receptor agonist, clonidine, reduces alcohol drinking in alcohol-preferring (P) rats

(2014) Dennis D. Rasmussen et al.   ALCOHOL

Differential Localization of G Protein βγ Subunits

(2014) Katherine M. Betke et al.   BIOCHEMISTRY

Modulation of Neurotransmission by GPCRs Is Dependent upon the Microarchitecture of the Primed Vesicle Complex

(2014) E. Hamid et al.   JOURNAL OF NEUROSCIENCE

 2A-Adrenergic Receptors Filter Parabrachial Inputs to the Bed Nucleus of the Stria Terminalis

(2014) S. A. Flavin et al.   JOURNAL OF NEUROSCIENCE

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

(2014) Nellie E Byun et al.   NEUROPSYCHOPHARMACOLOGY

The role of D2-autoreceptors in regulating dopamine neuron activity and transmission

(2014) C.P. Ford   NEUROSCIENCE

Neonatal Leptin Exposure Specifies Innervation of Presympathetic Hypothalamic Neurons and Improves the Metabolic Status of Leptin-Deficient Mice

(2013) K. Bouyer et al.   JOURNAL OF NEUROSCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

GPCR mediated regulation of synaptic transmission

(2012) Katherine M. Betke et al.   PROGRESS IN NEUROBIOLOGY

Are the pharmacology and physiology of α2adrenoceptors determined by α2-heteroreceptors and autoreceptors respectively?

(2011) Ralf Gilsbach et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gβγ and the C Terminus of SNAP-25 Are Necessary for Long-Term Depression of Transmitter Release

(2011) Xiao-lei Zhang et al.   PLoS One

The importance of norepinephrine in depression

(2011) Mike Briley et al.   Neuropsychiatric Disease and Treatment

G o Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic  -Cells

(2010) A. Zhao et al.   DIABETES

Noradrenaline inhibits exocytosis via the G protein βγ subunit and refilling of the readily releasable granule pool via the αi1/2subunit

(2010) Ying Zhao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors

(2010) John R Mantsch et al.   NEUROPSYCHOPHARMACOLOGY

Presynaptic G-Protein-Coupled Receptors Dynamically Modify Vesicle Fusion, Synaptic Cleft Glutamate Concentrations, and Motor Behavior

(2009) T. Gerachshenko et al.   JOURNAL OF NEUROSCIENCE

Retrograde Opioid Signaling Regulates Glutamatergic Transmission in the Hypothalamus

(2009) K. J. Iremonger et al.   JOURNAL OF NEUROSCIENCE

Genetic Dissection of  2-Adrenoceptor Functions in Adrenergic versus Nonadrenergic Cells

(2009) R. Gilsbach et al.   MOLECULAR PHARMACOLOGY

α2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis

(2009) A.D. Shields et al.   NEUROSCIENCE

Dopamine inhibits GABAA currents in ventral tegmental area dopamine neurons via activation of presynaptic G-protein coupled inwardly-rectifying potassium channels

(2009) A. Michaeli et al.   NEUROSCIENCE

Pre-synaptic GABABreceptors inhibit glutamate release through GIRK channels in rat cerebral cortex

(2008) Carolina Ladera et al.   JOURNAL OF NEUROCHEMISTRY

G protein βγ Subunits Modulate the Number and Nature of Exocytotic Fusion Events in Adrenal Chromaffin Cells Independent of Calcium Entry

(2008) Eun-Ja Yoon et al.   JOURNAL OF NEUROPHYSIOLOGY

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics

(2008) Q. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function

(2008) Jenny U. Johansson et al.   PLoS Genetics