Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?

Introduction to the Special Issue: “Making orexin-based therapies for addiction a reality: What are the steps from here?”

(2020) Morgan H. James et al.   BRAIN RESEARCH

Cocaine abuse and midbrain circuits: Functional anatomy of hypocretin/orexin transmission and therapeutic prospect

(2019) Steven J. Simmons et al.   BRAIN RESEARCH

The role of orexin-1 receptor signaling in demand for the opioid fentanyl

(2019) Jennifer E. Fragale et al.   NEUROPSYCHOPHARMACOLOGY

Preliminary examination of the orexin system on relapse-related factors in cocaine use disorder

(2019) Robert Suchting et al.   BRAIN RESEARCH

Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil

(2019) Aida Mohammadkhani et al.   BRAIN RESEARCH

A sleeping giant: Suvorexant for the treatment of alcohol use disorder?

(2018) Erin J. Campbell et al.   BRAIN RESEARCH

Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin-1 receptor antagonist in rats

(2018) Morgan H James et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

NIDA’s medication development priorities in response to the Opioid Crisis: ten most wanted

(2018) Kurt Rasmussen et al.   NEUROPSYCHOPHARMACOLOGY

Preclinical assessment of the abuse potential of the orexin receptor antagonist, suvorexant

(2017) Stephanie Born et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea

(2016) Hong Sun et al.   Journal of Clinical Sleep Medicine

Orexin Signaling in the VTA Gates Morphine-Induced Synaptic Plasticity

(2015) C. Baimel et al.   JOURNAL OF NEUROSCIENCE

On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy Volunteers

(2015) Annemiek Vermeeren et al.   SLEEP

On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy Volunteers

(2015) Annemiek Vermeeren et al.   SLEEP

Sleep disturbances and pain among individuals with prescription opioid dependence

(2014) Emily E. Hartwell et al.   ADDICTIVE BEHAVIORS

Hypocretin Receptor 2 Antagonism Dose-Dependently Reduces Escalated Heroin Self-Administration in Rats

(2014) Brooke E Schmeichel et al.   NEUROPSYCHOPHARMACOLOGY

Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats

(2012) Luyi Zhou et al.   NEUROPHARMACOLOGY

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY