Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype

Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder

(2019) Hyunpil Lee et al.   Translational Psychiatry

GeneAnalytics Pathways and Profiling of Shared Autism and Cancer Genes

(2019) Alexander Gabrielli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Moving beyond P values: data analysis with estimation graphics

(2019) Joses Ho et al.   NATURE METHODS

A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships

(2018) Taylor L. Mighell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

65 YEARS OF THE DOUBLE HELIX: One gene, many endocrine and metabolic syndromes: PTEN -opathies and precision medicine

(2018) Lamis Yehia et al.   ENDOCRINE-RELATED CANCER

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth

(2017) Catherine J. Fricano-Kugler et al.   BIOLOGICAL PSYCHIATRY

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

(2016) Sandra Goebbels et al.   NATURE NEUROSCIENCE

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated  -Catenin Signaling

(2015) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder

(2015) A K Tilot et al.   MOLECULAR PSYCHIATRY

Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice

(2015) Dario Cupolillo et al.   NEUROPSYCHOPHARMACOLOGY

Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder

(2015) Amanda K. Tilot et al.   Neurotherapeutics

Complement Pathway Is Frequently Altered in Endometriosis and Endometriosis-Associated Ovarian Cancer

(2014) S. Suryawanshi et al.   CLINICAL CANCER RESEARCH

Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production

(2014) A. K. Tilot et al.   HUMAN MOLECULAR GENETICS

Macrocephaly as a Clinical Indicator of Genetic Subtypes in Autism

(2013) Steven Klein et al.   Autism Research

Pten loss in the bone marrow leads to G-CSF–mediated HSC mobilization

(2013) Melania Tesio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lifetime Cancer Risks in Individuals with Germline PTEN Mutations

(2012) M.-H. Tan et al.   CLINICAL CANCER RESEARCH

Development and Characterization of NEX-Pten,a Novel Forebrain Excitatory Neuron-Specific Knockout Mouse

(2012) Tatiana M. Kazdoba et al.   DEVELOPMENTAL NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

PTEN Negatively Regulates Engulfment of Apoptotic Cells by Modulating Activation of Rac GTPase

(2011) S. Mondal et al.   JOURNAL OF IMMUNOLOGY

A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands

(2010) Min-Han Tan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

(2010) Emily P. Harrington et al.   ANNALS OF NEUROLOGY

The Role of Microglia in Synaptic Stripping and Synaptic Degeneration: A Revised Perspective

(2010) V Hugh Perry et al.   ASN Neuro

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NovelPTENmutations in neurodevelopmental disorders and macrocephaly

(2009) A Orrico et al.   CLINICAL GENETICS

The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly

(2009) Elizabeth A Varga et al.   GENETICS IN MEDICINE