Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into Regulation and Genetic Variation

Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice

(2017) Maarten van den Buuse et al.   SCHIZOPHRENIA RESEARCH

The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair

(2017) M Notaras et al.   Translational Psychiatry

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

(2016) Sumangali Kailainathan et al.   PHARMACOLOGICAL RESEARCH

Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling

(2016) Toshiyuki Mizui et al.   PHARMACOLOGICAL RESEARCH

BDNF pro-peptide regulates dendritic spines via caspase-3

(2016) J Guo et al.   Cell Death & Disease

BDNF Val66Met genotype determines hippocampus-dependent behavior via sensitivity to glucocorticoid signaling

(2015) M Notaras et al.   MOLECULAR PSYCHIATRY

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

(2015) M Notaras et al.   MOLECULAR PSYCHIATRY

A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review

(2015) Michael Notaras et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

(2015) Toshiyuki Mizui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

(2015) Marie-Pierre Péli-Gulli et al.   Cell Reports

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Transcriptome profiling analysis of the mechanisms underlying the BDNF Val66Met polymorphism induced dysfunctions of the central nervous system

(2013) Dong-Dong Wang et al.   HIPPOCAMPUS

TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders

(2013) Vivek Gupta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid beta1-42(Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway

(2013) Khalil Saadipour et al.   JOURNAL OF NEUROCHEMISTRY

Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures

(2013) Maria del Carmen Cardenas-Aguayo et al.   PLoS One

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

A systematic review and meta-analysis on the association between BDNF val66met and hippocampal volume-A genuine effect or a winners curse?

(2012) Marc L. Molendijk et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Variant Brain-Derived Neurotrophic Factor (Valine66Methionine) Polymorphism Contributes to Developmental and Estrous Stage-Specific Expression of Anxiety-Like Behavior in Female Mice

(2012) Kevin G. Bath et al.   BIOLOGICAL PSYCHIATRY

Truncated TrkB: Beyond a dominant negative receptor

(2012) Barbara M. Fenner   CYTOKINE & GROWTH FACTOR REVIEWS

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

(2012) Sandra Dieni et al.   JOURNAL OF CELL BIOLOGY

Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer’s disease

(2012) Jenny Wong et al.   JOURNAL OF NEUROCHEMISTRY

Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice

(2012) R. A. Hill et al.   JOURNAL OF NEUROENDOCRINOLOGY

Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

(2012) H. Yu et al.   JOURNAL OF NEUROSCIENCE

Sortilin and SorLA Regulate Neuronal Sorting of Trophic and Dementia-Linked Proteins

(2012) Lone Tjener Pallesen et al.   MOLECULAR NEUROBIOLOGY

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice

(2012) Maren Klug et al.   NEUROBIOLOGY OF DISEASE

BDNF Val66Met Impairs Fluoxetine-Induced Enhancement of Adult Hippocampus Plasticity

(2012) Kevin G Bath et al.   NEUROPSYCHOPHARMACOLOGY

Impact of the BDNF Val66Met Polymorphism on Cognition

(2012) Iva Dincheva et al.   NEUROSCIENTIST

ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA

(2012) Ying Sun et al.   PLoS One

Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor

(2012) Ioannis Charalampopoulos et al.   Cell Reports

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice

(2011) Rachel A. Hill et al.   BRAIN RESEARCH

Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing

(2011) Miao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

(2011) Sarah Felice Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments

(2011) G. Baj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Isoflurane Neurotoxicity Is Mediated by p75NTR-RhoA Activation and Actin Depolymerization

(2010) Brian P. Lemkuil et al.   ANESTHESIOLOGY

p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17

(2010) Rajappa S. Kenchappa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)

(2010) A. G. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Fear Extinction with Hippocampal-Infralimbic BDNF

(2010) J. Peters et al.   SCIENCE

Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice

(2009) Indrek Koppel et al.   BMC NEUROSCIENCE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation

(2009) C. Chiaruttini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis

(2009) Michael J. Colditz et al.   EXPERIMENTAL BRAIN RESEARCH

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo

(2008) M J M Bertrand et al.   CELL DEATH AND DIFFERENTIATION

The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours

(2008) Vibeke S. Catts et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Activation of pro-BDNF by the pericellular serine protease plasmin

(2008) Kelly Gray et al.   FEBS LETTERS

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Aβ1–42 stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor

(2008) Areechun Sotthibundhu et al.   NEUROBIOLOGY OF AGING

The p75 neurotrophin receptor

(2007) Clare K. Underwood et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by γ-secretase

(2007) Clare K. Underwood et al.   MOLECULAR AND CELLULAR NEUROSCIENCE