Site-specific N-glycan Analysis of Antibody-binding Fc γ Receptors from Primary Human Monocytes

Modeling Glycan Processing Reveals Golgi-Enzyme Homeostasis upon Trafficking Defects and Cellular Differentiation

(2019) Peter Fisher et al.   Cell Reports

Primary human natural killer cells retain proinflammatory IgG1 at the cell surface and express CD16a glycoforms with donor-dependent variability

(2019) Kashyap R Patel et al.   MOLECULAR & CELLULAR PROTEOMICS

Antibody fucosylation lowers FcγRIIIa/CD16a affinity by limiting the conformations sampled by the N162-glycan

(2018) Daniel J. Falconer et al.   ACS Chemical Biology

Restricted processing of CD16a/Fc γ receptor IIIaN-glycans from primary human NK cells impacts structure and function

(2018) Kashyap R. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific N-glycosylation analysis of soluble Fcγ receptor IIIb in human serum

(2018) Hirokazu Yagi et al.   Scientific Reports

CD16a with oligomannose-type N-glycans is the only “low affinity” Fc γ receptor that binds the IgG crystallizable fragment with high affinity in vitro

(2018) Ganesh P Subedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single amino acid distorts the Fc γ receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a

(2018) Jacob T. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of endogenous human FcγRIII by mass spectrometry reveals site, allele and sequence specific glycosylation

(2018) Nathaniel Washburn et al.   MOLECULAR & CELLULAR PROTEOMICS

Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

(2018) Gurpanna Saggu et al.   Nature Communications

Identification of Fc Gamma Receptor Glycoforms That Produce Differential Binding Kinetics for Rituximab

(2017) Jerrard M. Hayes et al.   MOLECULAR & CELLULAR PROTEOMICS

Elimination of erroneous results in flow cytometry caused by antibody binding to Fc receptors on human monocytes and macrophages

(2016) Morten N. Andersen et al.   CYTOMETRY PART A

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor

(2016) Ganesh P. Subedi et al.   mAbs

CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes

(2016) Wei Hseun Yeap et al.   Scientific Reports

bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression

(2015) Sina Gordan et al.   IMMUNOLOGICAL REVIEWS

The galectin lattice at a glance

(2015) I. R. Nabi et al.   JOURNAL OF CELL SCIENCE

NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

(2015) Wei Wang   Frontiers in Immunology

Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology

(2015) Jonathan J. Lyons et al.   Frontiers in Pediatrics

Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells

(2015) Yawu Jing et al.   PLoS One

Intramolecular N-Glycan/Polypeptide Interactions Observed at Multiple N-Glycan Remodeling Steps through [13C,15N]-N-Acetylglucosamine Labeling of Immunoglobulin G1

(2014) Adam W. Barb   BIOCHEMISTRY

Glycoengineering of Therapeutic Antibodies Enhances Monocyte/Macrophage-Mediated Phagocytosis and Cytotoxicity

(2014) S. Herter et al.   JOURNAL OF IMMUNOLOGY

Fc Gamma Receptor Glycosylation Modulates the Binding of IgG Glycoforms: A Requirement for Stable Antibody Interactions

(2014) Jerrard M. Hayes et al.   JOURNAL OF PROTEOME RESEARCH

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

ADAM17-Mediated Shedding of Fc RIIIA on Human NK Cells: Identification of the Cleavage Site and Relationship with Activation

(2013) L. Lajoie et al.   JOURNAL OF IMMUNOLOGY

ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils

(2012) Yue Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The GlycanBuilder and GlycoWorkbench glycoinformatics tools: updates and new developments

(2012) David Damerell et al.   BIOLOGICAL CHEMISTRY

A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies

(2012) L. H. Sehn et al.   BLOOD

GA201 (RG7160): A Novel, Humanized, Glycoengineered Anti-EGFR Antibody with Enhanced ADCC and Superior In Vivo Efficacy Compared with Cetuximab

(2012) C. A. Gerdes et al.   CLINICAL CANCER RESEARCH

Obinutuzumab (GA101) – a different anti-CD20 antibody with great expectations

(2012) Tim M Illidge   EXPERT OPINION ON BIOLOGICAL THERAPY

Regulation of Glycan Structures in Murine Embryonic Stem Cells

(2012) Alison V. Nairn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Monocyte Subsets Responsible for Immunoglobulin G-Dependent Effector Functions In Vivo

(2011) Markus Biburger et al.   IMMUNITY

Cell Type-Specific and Site DirectedN-Glycosylation Pattern of FcγRIIIa

(2011) Anne Zeck et al.   JOURNAL OF PROTEOME RESEARCH

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages

(2009) François Trottein et al.   GLYCOCONJUGATE JOURNAL

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Trastuzumab-Based Therapy in Patients With HER-2/neu–Positive Metastatic Breast Cancer

(2008) Antonino Musolino et al.   JOURNAL OF CLINICAL ONCOLOGY