A single amino acid distorts the Fc γ receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a

Antibody fucosylation lowers FcγRIIIa/CD16a affinity by limiting the conformations sampled by the N162-glycan

(2018) Daniel J. Falconer et al.   ACS Chemical Biology

Restricted processing of CD16a/Fc γ receptor IIIaN-glycans from primary human NK cells impacts structure and function

(2018) Kashyap R. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific N-glycosylation analysis of soluble Fcγ receptor IIIb in human serum

(2018) Hirokazu Yagi et al.   Scientific Reports

CD16a with oligomannose-type N-glycans is the only “low affinity” Fc γ receptor that binds the IgG crystallizable fragment with high affinity in vitro

(2018) Ganesh P Subedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Fc Gamma Receptor Glycoforms That Produce Differential Binding Kinetics for Rituximab

(2017) Jerrard M. Hayes et al.   MOLECULAR & CELLULAR PROTEOMICS

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

(2017) James I. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

(2017) Gillian Dekkers et al.   Frontiers in Immunology

The influence of NK cell-mediated ADCC: Structure and expression of the CD16 molecule differ among FcγRIIIa-V158F genotypes in healthy Japanese subjects

(2016) Wataru Oboshi et al.   HUMAN IMMUNOLOGY

The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor

(2016) Ganesh P. Subedi et al.   mAbs

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions

(2015) Simone Battella et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity

(2015) Marco Thomann et al.   PLoS One

Restricted Motion of the Conserved Immunoglobulin G1 N-Glycan Is Essential for Efficient FcγRIIIa Binding

(2014) Ganesh P. Subedi et al.   STRUCTURE

Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab

(2013) J. Golay et al.   BLOOD

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

(2013) James D Mellor et al.   Journal of Hematology & Oncology

NMR Characterization of Immunoglobulin G Fc Glycan Motion on Enzymatic Sialylation

(2012) Adam W. Barb et al.   BIOCHEMISTRY

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

(2011) Tsunehiro Mizushima et al.   GENES TO CELLS

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Nonfucosylated rituximab potentiates human neutrophil phagocytosis through its high binding for FcγRIIIb and MHC class II expression on the phagocytotic neutrophils

(2009) Mami Shibata-Koyama et al.   EXPERIMENTAL HEMATOLOGY

Human Basophils Express the Glycosylphosphatidylinositol-Anchored Low-Affinity IgG Receptor Fc RIIIB (CD16B)

(2009) N. Meknache et al.   JOURNAL OF IMMUNOLOGY

Fc RIIIa Expression Is Not Increased on Natural Killer Cells Expressing the Fc RIIIa-158V Allotype

(2008) N. Congy-Jolivet et al.   CANCER RESEARCH

The N-linked oligosaccharide at Fc RIIIa Asn-45: an inhibitory element for high Fc RIIIa binding affinity to IgG glycoforms lacking core fucosylation

(2008) M. Shibata-Koyama et al.   GLYCOBIOLOGY