Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites

(2019) Xingxing Diao et al.   Frontiers in Chemistry

Cannabis and Male Fertility: A Systematic Review

(2019) Kelly S. Payne et al.   JOURNAL OF UROLOGY

Synthetic cannabinoid receptor agonists: classification and nomenclature

(2019) A. J. Potts et al.   CLINICAL TOXICOLOGY

Evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil by ultra-high-performance liquid chromatography tandem mass spectrometry

(2018) Roberta Pacifici et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Simple screening procedure for 72 synthetic cannabinoids in whole blood by liquid chromatography–tandem mass spectrometry

(2018) Katarzyna Ambroziak et al.   Forensic Toxicology

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers

(2018) Jacob Atsmon et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for ocular drug delivery

(2018) Maryam Kabiri et al.   Drug Delivery and Translational Research

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells

(2018) Chiara Russo et al.   ARCHIVES OF TOXICOLOGY

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal

(2018) Ai-Ling Li et al.   MOLECULAR PHARMACOLOGY

A Public Health Strategy for the Opioid Crisis

(2018) Brendan Saloner et al.   PUBLIC HEALTH REPORTS

Cannabinoids and Pain: New Insights From Old Molecules

(2018) Sonja Vučković et al.   Frontiers in Pharmacology

The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model

(2017) Irina Cherniakov et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients

(2017) Sebastian Schimrigk et al.   EUROPEAN NEUROLOGY

Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration

(2017) Irina Cherniakov et al.   JOURNAL OF CONTROLLED RELEASE

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

(2017) Paula Morales et al.   Frontiers in Pharmacology

Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4

(2016) Franziska Ferk et al.   ARCHIVES OF TOXICOLOGY

Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells

(2016) Sindiswa T. Lukhele et al.   BMC Complementary and Alternative Medicine

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

Focus on cannabinoids and synthetic cannabinoids

(2016) R Le Boisselier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites

(2016) X Diao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Epidemiology and clinical features of toxicity following recreational use of synthetic cannabinoid receptor agonists: a report from the United Kingdom National Poisons Information Service

(2016) Jennifer Waugh et al.   CLINICAL TOXICOLOGY

Cell Proliferation and Cytotoxicity Assays

(2016) Aysun Adan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial

(2016) Z. Malik et al.   DISEASES OF THE ESOPHAGUS

The endocannabinoid system and neuropathic pain

(2016) Rafael Maldonado et al.   PAIN

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation

(2016) Fei Yang et al.   PAIN

Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and Withdrawal

(2016) Ziva D. Cooper   Current Psychiatry Reports

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

(2016) Jaesuk Yun et al.   Toxicology Research

The drug situation in Europe: an overview of data available on illicit drugs and new psychoactive substances from European monitoring in 2015

(2015) Jane Mounteney et al.   ADDICTION

Synthetic Cannabinoids

(2015) Brooke Mills et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Determination and identification of synthetic cannabinoids and their metabolites in different matrices by modern analytical techniques – a review

(2015) Joanna Znaleziona et al.   ANALYTICA CHIMICA ACTA

Bioluminescence assay for cell viability

(2015) G. Yu. Lomakina et al.   BIOCHEMISTRY-MOSCOW

Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

(2015) Liting Deng et al.   BIOLOGICAL PSYCHIATRY

Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210

(2015) Hye Jin Cha et al.   Biomolecules & Therapeutics

Teenage Cardiac Arrest Following Abuse of Synthetic Cannabis

(2015) C. Davis et al.   Heart Lung and Circulation

Synthetic cannabinoids: Epidemiology, pharmacodynamics, and clinical implications

(2014) Marisol S. Castaneto et al.   DRUG AND ALCOHOL DEPENDENCE

Cellular approaches to the interaction between cannabinoid receptor ligands and nicotinic acetylcholine receptors

(2014) Murat Oz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands

(2014) Mellar P Davis   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

(2014) Elizabeth J Rahn et al.   Molecular Pain

Adverse Health Effects of Marijuana Use

(2014) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations

(2014) Jennifer S. Gewandter et al.   PAIN

LC/ESI-MS/MS method for quantification of 28 synthetic cannabinoids in neat oral fluid and its application to preliminary studies on their detection windows

(2013) Stefan Kneisel et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids

(2013) Christopher Y. Hopkins et al.   JOURNAL OF EMERGENCY MEDICINE

The XTT Cell Proliferation Assay Applied to Cell Layers Embedded in Three-Dimensional Matrix

(2012) Lynn Huyck et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons

(2012) Gabor Veress et al.   Brain Structure & Function

Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis

(2012) Giulio Podda et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Detection and disposition of JWH-018 and JWH-073 in mice after exposure to “Magic Gold” smoke

(2012) Justin L. Poklis et al.   FORENSIC SCIENCE INTERNATIONAL

Detection and Quantification of New Designer Drugs in Human Blood: Part 1 - Synthetic Cannabinoids

(2012) J. Ammann et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction

(2012) Stefan Kneisel et al.   JOURNAL OF MASS SPECTROMETRY

Polypharmacology: drug discovery for the future

(2012) A Srinivas Reddy et al.   Expert Review of Clinical Pharmacology

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Cannabinoid–Opioid Interaction in Chronic Pain

(2011) D I Abrams et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Identification and Quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in Human Whole Blood

(2011) S. L. Kacinko et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitation of synthetic cannabinoids of the aminoalkylindole type and methanandamide in serum and its application to forensic samples

(2011) Sebastian Dresen et al.   JOURNAL OF MASS SPECTROMETRY

In vitro phase I metabolism of the synthetic cannabimimetic JWH-018

(2010) Annette Wintermeyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography–tandem mass spectrometry

(2010) Jörg Teske et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects

(2010) Steven G. Kinsey et al.   NEUROPHARMACOLOGY

Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells

(2010) Donna A. Whyte et al.   PHARMACOLOGY

A Basis for Reduced Chemical Library Inhibition of Firefly Luciferase Obtained from Directed Evolution

(2009) Douglas S. Auld et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside

(2009) Elizabeth J. Rahn et al.   Neurotherapeutics

Therapeutic potential of cannabis in pain medicine † †Declaration of interest. The authors have received funding from the Medical Research Council and the South West Regional Development Agency.

(2008) R.D. Hosking et al.   BRITISH JOURNAL OF ANAESTHESIA

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain

(2008) Wataru Yamamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

(2007) E J Rahn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of Dronabinol as an Adjuvant Treatment for Chronic Pain Patients on Opioid Therapy

(2007) Sanjeet Narang et al.   JOURNAL OF PAIN

Cannabinoid pharmacology: the first 66 years

(2006) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY