Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus

(2018) Rishi Sharma et al.   JOURNAL OF PINEAL RESEARCH

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery

(2018) Tobias Atkin et al.   PHARMACOLOGICAL REVIEWS

Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep

(2018) Gabriella Gobbi et al.   JOURNAL OF PINEAL RESEARCH

Day/night expression of MT 1 and MT 2 receptors in hypothalamic nuclei of the primate Sapajus apella

(2017) Luciana Pinato et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Neural Circuitry of Wakefulness and Sleep

(2017) Thomas E. Scammell et al.   NEURON

Endogenous Melatonin is Not Obligatory for the Regulation of the Rat Sleep-Wake Cycle

(2017) Simon P. Fisher et al.   SLEEP

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antinociceptive properties of selective MT2 melatonin receptor partial agonists

(2015) Martha López-Canul et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melancholic-Like Behaviors and Circadian Neurobiological Abnormalities in Melatonin MT1 Receptor Knockout Mice

(2015) S. Comai et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2CReceptor Heteromers

(2015) Maud Kamal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anatomical and cellular localization of melatonin MT1and MT2receptors in the adult rat brain

(2015) Baptiste Lacoste et al.   JOURNAL OF PINEAL RESEARCH

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways

(2015) Martha Lopez-Canul et al.   PAIN

Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration

(2014) Giulio Tononi et al.   NEURON

Melatonin, selective and non-selective MT1/MT2 receptors agonists: Differential effects on the 24-h vigilance states

(2014) Rafael Ochoa-Sanchez et al.   NEUROSCIENCE LETTERS

Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain

(2014) Yuan-Yuan Liu et al.   PSYCHOPHARMACOLOGY

Sleep–wake characterization of double MT1/MT2 receptor knockout mice and comparison with MT1 and MT2 receptor knockout mice

(2013) Stefano Comai et al.   BEHAVIOURAL BRAIN RESEARCH

Sleep and emotions: Bidirectional links and underlying mechanisms

(2013) Michal Kahn et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

(2013) Esther Parada et al.   JOURNAL OF PINEAL RESEARCH

Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function

(2013) K. Baba et al.   Science Signaling

Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6

(2012) Rituraj Niranjan et al.   FREE RADICAL RESEARCH

Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications

(2011) Sooyoung Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2 Melatonin Receptor Ligand

(2011) R. Ochoa-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Melatonin has membrane receptor-independent hypnotic action on neurons: an hypothesis

(2011) James E. Jan et al.   JOURNAL OF PINEAL RESEARCH

Circadian regulation of pineal gland rhythmicity

(2011) Jimo Borjigin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sleep-waking discharge profiles of median preoptic and surrounding neurons in mice

(2011) K. Sakai   NEUROSCIENCE

Characterization of the bout durations of sleep and wakefulness

(2010) Blakeley B. McShane et al.   JOURNAL OF NEUROSCIENCE METHODS

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Optogenetic deconstruction of sleep-wake circuitry in the brain

(2010) Antoine Adamantidis   Frontiers in Molecular Neuroscience

Contribution of the daily melatonin profile to diagnosis of tumors of the pineal region

(2009) José Leston et al.   JOURNAL OF NEURO-ONCOLOGY

Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat

(2009) Simon P. Fisher et al.   NEUROSCIENCE LETTERS

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

(2009) Amandine Descamps et al.   PSYCHOPHARMACOLOGY

Activation of 5-HT2C receptors acutely induces Per1 gene expression in the rat SCN in vitro

(2008) Tamara J. Varcoe et al.   BRAIN RESEARCH

Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat

(2008) Simon P. Fisher et al.   JOURNAL OF PINEAL RESEARCH

Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials

(2008) Shantha MW Rajaratnam et al.   LANCET

Slow-wave sleep and the risk of type 2 diabetes in humans

(2008) E. Tasali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA