TRESK background K + channel deletion selectively uncovers enhanced mechanical and cold sensitivity

Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties

(2019) Yang Zheng et al.   NEURON

The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing

(2019) Greg A. Weir et al.   Frontiers in Molecular Neuroscience

A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene

(2019) Jianke Gong et al.   CELL

Pyrethroids inhibit K2P channels and activate sensory neurons

(2018) Aida Castellanos et al.   PAIN

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

(2018) Rahul Dhandapani et al.   Nature Communications

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK

(2018) Perrine Royal et al.   NEURON

Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis

(2018) Yue Yang et al.   Science Signaling

PIEZO2 mediates injury-induced tactile pain in mice and humans

(2018) Marcin Szczot et al.   Science Translational Medicine

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

(2018) Swetha E. Murthy et al.   Science Translational Medicine

TRPA1 expression levels and excitability brake by K V channels influence cold sensitivity of TRPA1-expressing neurons

(2017) Tosifa Memon et al.   NEUROSCIENCE

Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse

(2017) Zoltan Winter et al.   Frontiers in Molecular Neuroscience

Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing

(2017) Minh Q. Nguyen et al.   PLoS One

New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives

(2016) Stéphane Lolignier et al.   JOURNAL OF NEUROSCIENCE

Coding and Plasticity in the Mammalian Thermosensory System

(2016) David A. Yarmolinsky et al.   NEURON

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

(2015) Chang-Lin Li et al.   CELL RESEARCH

Acid-sensing ion channels detect moderate acidifications to induce ocular pain

(2015) Gerard Callejo et al.   PAIN

RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors

(2015) Caroline Flegel et al.   PLoS One

Activation of TRESK channels by the inflammatory mediator lysophosphatidic acid balances nociceptive signalling

(2015) Sina Kollert et al.   Scientific Reports

TREK2 Expressed Selectively in IB4-Binding C-Fiber Nociceptors Hyperpolarizes Their Membrane Potentials and Limits Spontaneous Pain

(2014) C. Acosta et al.   JOURNAL OF NEUROSCIENCE

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Peripheral thermosensation in mammals

(2014) Joris Vriens et al.   NATURE REVIEWS NEUROSCIENCE

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception

(2014) Vanessa Pereira et al.   PAIN

Over-Expression of TRESK K+ Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors

(2014) Zhaohua Guo et al.   PLoS One

The functional and anatomical dissection of somatosensory subpopulations using mouse genetics

(2014) Claire E. Le Pichon et al.   Frontiers in Neuroanatomy

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

(2014) Isaac M Chiu et al.   eLife

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

(2013) Jun Zhou et al.   NEUROREPORT

BKCa channels expressed in sensory neurons modulate inflammatory pain in mice

(2013) Ruirui Lu et al.   PAIN

The interphase of the formalin test

(2013) Michael Fischer et al.   PAIN

Modulation of TRESK Background K+ Channel by Membrane Stretch

(2013) Gerard Callejo et al.   PLoS One

Comprehensive RNA-Seq Expression Analysis of Sensory Ganglia with a Focus on Ion Channels and GPCRs in Trigeminal Ganglia

(2013) Stavros Manteniotis et al.   PLoS One

Leak K+ channel mRNAs in dorsal root ganglia: Relation to inflammation and spontaneous pain behaviour

(2012) Barnaby Marsh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons

(2012) JUN ZHOU et al.   Molecular Medicine Reports

A Novel Behavioral Assay for Measuring Cold Sensation in Mice

(2012) Daniel S. Brenner et al.   PLoS One

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

TRESK Channel Contribution to Nociceptive Sensory Neurons Excitability: Modulation by Nerve Injury

(2011) Astrid Tulleuda et al.   Molecular Pain

Discrete Change in Volatile Anesthetic Sensitivity in Mice with Inactivated Tandem Pore Potassium Ion Channel TRESK

(2010) Yun Jeong Chae et al.   ANESTHESIOLOGY

TRESK Background K+Channel Is Inhibited by Phosphorylation via Two Distinct Pathways

(2010) Gábor Czirják et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

(2010) Ronald G Lafrenière et al.   NATURE MEDICINE

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

(2009) Jacques Noël et al.   EMBO JOURNAL

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

(2009) R. Madrid et al.   JOURNAL OF NEUROSCIENCE

Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents

(2009) Ipek Yalcin et al.   JOURNAL OF PAIN

Phenotyping sensory nerve endings in vitro in the mouse

(2009) Katharina Zimmermann et al.   Nature Protocols

Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells

(2009) Yoshio Yamamoto et al.   NEUROSCIENCE LETTERS

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

(2008) Diana M Bautista et al.   NATURE NEUROSCIENCE

Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons

(2008) M. R. C. Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA