Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

The endocannabinoid system as a target for novel anxiolytic drugs

(2017) Sachin Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats

(2017) Erin M. Rock et al.   PSYCHOPHARMACOLOGY

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

(2017) Rebecca J. Bluett et al.   Nature Communications

Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience

(2017) Mathilde S. Henry et al.   NEURAL PLASTICITY

Mood Therapeutics: Novel Pharmacological Approaches for Treating Depression

(2017) Ioline D. Henter et al.   Expert Review of Clinical Pharmacology

Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala

(2016) S. Di et al.   JOURNAL OF NEUROSCIENCE

Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety

(2016) Maria Morena et al.   NEUROPHARMACOLOGY

Endocannabinoids and stress

(2016) Caitlin J. Riebe et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs

(2015) Elena Dale et al.   BIOCHEMICAL PHARMACOLOGY

Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats

(2015) Antonia Manduca et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The potential of inhibitors of endocannabinoid metabolism as anxiolytic and antidepressive drugs—A practical view

(2015) Christopher J. Fowler   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The endocannabinoid system in guarding against fear, anxiety and stress

(2015) Beat Lutz et al.   NATURE REVIEWS NEUROSCIENCE

Neurobiological Interactions Between Stress and the Endocannabinoid System

(2015) Maria Morena et al.   NEUROPSYCHOPHARMACOLOGY

Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink

(2015) Georgina Nakafero et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Effects of URB597 as an inhibitor of fatty acid amide hydrolase on WIN55, 212-2-induced learning and memory deficits in rats

(2015) Parisa Hasanein et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats

(2015) Leigh V. Panlilio et al.   PSYCHOPHARMACOLOGY

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

(2015) Guy Griebel et al.   Scientific Reports

Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress

(2014) Gaurav Bedse et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The endocannabinoid system: An emotional buffer in the modulation of memory function

(2014) Maria Morena et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184

(2014) Alexandre Seillier et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome

(2014) Larisa V. Lysenko et al.   PLoS One

Control of synaptic function by endocannabinoid-mediated retrograde signaling

(2014) Masanobu KANO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

(2014) Daniel J. Hermanson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

(2014) R J Bluett et al.   Translational Psychiatry

Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling

(2013) Rongqing Chen et al.   CELL

Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice

(2013) Mano Aliczki et al.   HORMONES AND BEHAVIOR

50 years of hurdles and hope in anxiolytic drug discovery

(2013) Guy Griebel et al.   NATURE REVIEWS DRUG DISCOVERY

Dissociation of the Pharmacological Effects of THC by mTOR Blockade

(2013) Emma Puighermanal et al.   NEUROPSYCHOPHARMACOLOGY

Dual Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Blockade Produces THC-Like Morris Water Maze Deficits in Mice

(2012) Laura E. Wise et al.   ACS Chemical Neuroscience

Multiple Functions of Endocannabinoid Signaling in the Brain

(2012) István Katona et al.   Annual Review of Neuroscience

The temporal dynamics of the effects of monoacylglycerol lipase blockade on locomotion, anxiety, and body temperature

(2012) Mano Aliczki et al.   BEHAVIOURAL PHARMACOLOGY

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission

(2012) Alejandro Aparisi Rey et al.   NEUROPSYCHOPHARMACOLOGY

Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses

(2011) Arnau Busquets-Garcia et al.   BIOLOGICAL PSYCHIATRY

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

(2011) Natale R. Sciolino et al.   PHARMACOLOGICAL RESEARCH

Endogenous cannabinoid signaling is essential for stress adaptation

(2010) M. N. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent Mice

(2009) Joel E. Schlosburg et al.   AAPS Journal

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission

(2009) W. Jacob et al.   GENES BRAIN AND BEHAVIOR

Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats

(2009) J. Haller et al.   PSYCHOPHARMACOLOGY