Long‐term histological analysis of innervation and macrophage infiltration in a mouse model of intervertebral disc injury–induced low back pain

Changes in Nerve Growth Factor Expression and Macrophage Phenotype Following Intervertebral Disc Injury in Mice

(2019) Mitsufumi Nakawaki et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

(2018) Gregory James et al.   EUROPEAN SPINE JOURNAL

Nerves and blood vessels in degenerated intervertebral discs are confined to physically disrupted tissue

(2018) Polly Lama et al.   JOURNAL OF ANATOMY

Macrophage-derived inflammatory cytokines regulate growth factors and pain-related molecules in mice with intervertebral disc injury

(2018) Masayuki Miyagi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

In Vivo Mouse Intervertebral Disc Degeneration Model Based on a New Histological Classification

(2016) Takashi Ohnishi et al.   PLoS One

The Prevalence of Chronic Pain in Canada

(2016) Donald Schopflocher et al.   Pain Research & Management

Assessment of functional and behavioral changes sensitive to painful disc degeneration

(2015) Alon Lai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

Behavioral signs of axial low back pain and motor impairment correlate with the severity of intervertebral disc degeneration in a mouse model

(2015) Magali Millecamps et al.   Spine Journal

Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors

(2014) Emerson Krock et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ISSLS Prize Winner

(2014) Masayuki Miyagi et al.   SPINE

Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?

(2014) Yasuchika Aoki et al.   ARTHRITIS RESEARCH & THERAPY

Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration

(2013) John T. Martin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study

(2013) M. Teraguchi et al.   OSTEOARTHRITIS AND CARTILAGE

Assessment of Pain Behavior in a Rat Model of Intervertebral Disc Injury Using the Catwalk Gait Analysis System

(2013) Masayuki Miyagi et al.   SPINE

Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats

(2012) Toru Takada et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1

(2012) Jianru Wang et al.   ARTHRITIS AND RHEUMATISM

Activated Macrophage-Like THP-1 Cells Modulate Anulus Fibrosus Cell Production of Inflammatory Mediators in Response to Cytokines

(2010) Joo Han Kim et al.   SPINE

Innervation of Anulus Tears

(2010) Andrew B. Fagan et al.   SPINE

Therapeutic effects of adenovirus-mediated growth and differentiation factor-5 in a mice disc degeneration model induced by annulus needle puncture

(2009) Haixiang Liang et al.   Spine Journal

Matrix Remodeling During Intervertebral Disc Growth and Degeneration Detected by Multichromatic FAST Staining

(2008) Victor Y.L. Leung et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY