Parkinson’s disease and iron

Reproducible detection of nigral iron deposition in 2 Parkinson's disease cohorts

(2019) Jason Langley et al.   MOVEMENT DISORDERS

Impaired iPLA2β activity affects iron uptake and storage without iron accumulation: An in vitro study excluding decreased iPLA2β activity as the cause of iron deposition in PLAN

(2019) Yu-pei Guo et al.   BRAIN RESEARCH

Ventral posterior substantia nigra iron increases over 3 years in Parkinson's disease

(2019) Niels Bergsland et al.   MOVEMENT DISORDERS

The Association of Iron and the Pathologies of Parkinson’s Diseases in MPTP/MPP+-Induced Neuronal Degeneration in Non-human Primates and in Cell Culture

(2019) Liangqin Shi et al.   Frontiers in Aging Neuroscience

The role of iron in Parkinson's disease monkeys assessed by susceptibility weighted imaging and inductively coupled plasma mass spectrometry

(2019) Shao-Jun Li et al.   LIFE SCIENCES

Comprehensive MRI quantification of the substantia nigra pars compacta in Parkinson’s disease

(2018) H. Takahashi et al.   EUROPEAN JOURNAL OF RADIOLOGY

Life span pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI

(2018) Yue Xing et al.   MOVEMENT DISORDERS

Alpha-synuclein and iron: two keys unlocking Parkinson’s disease

(2017) Paul Lingor et al.   JOURNAL OF NEURAL TRANSMISSION

Association of freezing of gait with nigral iron accumulation in patients with Parkinson's disease

(2017) Rajini M. Naduthota et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease: a cross-sectional study of iron-related magnetic resonance imaging susceptibility

(2016) A. Martin-Bastida et al.   EUROPEAN JOURNAL OF NEUROLOGY

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

(2016) Chuang Guo et al.   EXPERIMENTAL NEUROLOGY

Regulation of ATP13A2 via PHD2-HIF1  Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

(2016) S. Rajagopalan et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

(2016) Jian-Yong Wang et al.   Scientific Reports

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

(2015) David I. Finkelstein et al.   ACS Chemical Neuroscience

The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity

(2015) Débora E. Rinaldi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

Neuroaxonal dystrophy inPLA2G6knockout mice

(2015) Hisae Sumi-Akamaru et al.   NEUROPATHOLOGY

Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1

(2015) Goichi Beck et al.   PLoS One

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron levels in the human brain: A post-mortem study of anatomical region differences and age-related changes

(2013) Patrícia Ramos et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Higher iron in the red nucleus marks Parkinson's dyskinesia

(2012) Mechelle M. Lewis et al.   NEUROBIOLOGY OF AGING

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders

(2011) Yu Lu et al.   ACS Chemical Neuroscience

Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A2  Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes

(2011) G. Beck et al.   JOURNAL OF NEUROSCIENCE

Increased Iron in the Substantia Nigra Compacta of the MPTP-Lesioned Hemiparkinsonian African Green Monkey: Evidence from Proton Microprobe Elemental Microanalysis

(2010) J. A. Temlett et al.   JOURNAL OF NEUROCHEMISTRY

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation

(2010) Susanne A. Schneider et al.   MOVEMENT DISORDERS

Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability

(2010) Lucio Santoro et al.   NEUROGENETICS

Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism

(2010) H. Yoshino et al.   NEUROLOGY

Restoration of Nigrostriatal Dopamine Neurons in Post-MPTP Treatment by the Novel Multifunctional Brain-Permeable Iron Chelator-Monoamine Oxidase Inhibitor Drug, M30

(2009) Shunit Gal et al.   NEUROTOXICITY RESEARCH

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

(2009) Wei Zhang et al.   NEUROTOXICITY RESEARCH

Characterization of PLA2G6 as a locus for dystonia-parkinsonism

(2008) Coro Paisan-Ruiz et al.   ANNALS OF NEUROLOGY

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY