Antagonistic Pleiotropy in Human Disease

Dominance reversals and the maintenance of genetic variation for fitness

(2019) Tim Connallon et al.   PLOS BIOLOGY

The “cancer–cold” hypothesis and possible extensions for the Nordic populations

(2019) Konstantinos Voskarides   SCANDINAVIAN JOURNAL OF PUBLIC HEALTH

Using Geographic Distance as a Potential Proxy for Help in the Assessment of the Grandmother Hypothesis

(2019) Sacha C. Engelhardt et al.   CURRENT BIOLOGY

Identifying loci under positive selection in complex population histories

(2019) Alba Refoyo-Martínez et al.   GENOME RESEARCH

CCR5-∆32 is deleterious in the homozygous state in humans

(2019) Xinzhu Wei et al.   NATURE MEDICINE

Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease

(2019) Erping Long et al.   Nature Ecology & Evolution

Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease

(2019) Juan Antonio Rodríguez et al.   Nature Ecology & Evolution

Involvement of SPATA31 copy number variable genes in human lifespan

(2018) Cemalettin Bekpen et al.   Aging-US

Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis

(2018) Gerard Muntané et al.   MOLECULAR BIOLOGY AND EVOLUTION

The transition to modernity and chronic disease: mismatch and natural selection

(2018) Stephen Corbett et al.   NATURE REVIEWS GENETICS

Horizons in the evolution of aging

(2018) Thomas Flatt et al.   BMC BIOLOGY

Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort

(2018) Jingmei Li et al.   INTERNATIONAL JOURNAL OF CANCER

Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia

(2018) Naoko T. Fujito et al.   PLoS One

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Apolipoprotein ε4 is associated with better cognitive control allocation in healthy young adults

(2018) Nicolas Zink et al.   NEUROIMAGE

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Selective Pressures on Human Cancer Genes along the Evolution of Mammals

(2018) Alberto Vicens et al.   Genes

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

(2017) Karoline B. Kuchenbaecker et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation

(2017) Konstantinos Voskarides   MOLECULAR BIOLOGY AND EVOLUTION

Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk

(2017) Terence D Capellini et al.   NATURE GENETICS

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

(2017) Sean G. Byars et al.   PLoS Genetics

Antagonistic pleiotropy and mutation accumulation influence human senescence and disease

(2017) Juan Antonio Rodríguez et al.   Nature Ecology & Evolution

Effect of APOE ε4 allele on survival and fertility in an adverse environment

(2017) Eric van Exel et al.   PLoS One

Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis

(2016) Guanlin Wang et al.   Cell Metabolism

Genomic prediction of coronary heart disease

(2016) Gad Abraham et al.   EUROPEAN HEART JOURNAL

The Prevalence of Huntington's Disease

(2016) Michael D. Rawlins et al.   NEUROEPIDEMIOLOGY

Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption

(2015) Kaixiong Ye et al.   BMC GENETICS

Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone

(2015) Mikael Mokkonen et al.   Evolutionary Applications

BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures

(2015) Carolina Medina-Gómez et al.   MOLECULAR BIOLOGY AND EVOLUTION

Androgen Receptor Gene Polymorphism, Aggression, and Reproduction in Tanzanian Foragers and Pastoralists

(2015) Marina L. Butovskaya et al.   PLoS One

Malaria continues to select for sickle cell trait in Central Africa

(2015) Eric Elguero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

(2015) G. Jasienska et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Early-late life trade-offs and the evolution of ageing in the wild

(2015) J.-F. Lemaitre et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A highly pleiotropic amino acid polymorphism in theDrosophilainsulin receptor contributes to life-history adaptation

(2014) Annalise B. Paaby et al.   EVOLUTION

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Can Evidence from Genome-Wide Association Studies and Positive Natural Selection Surveys Be Used to Evaluate the Thrifty Gene Hypothesis in East Asians?

(2014) Xuan-Han Koh et al.   PLoS One

Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes

(2014) Sheli L. Ostrow et al.   PLoS Genetics

Detecting and Characterizing Genomic Signatures of Positive Selection in Global Populations

(2013) Xuanyao Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detecting Natural Selection in Genomic Data

(2013) Joseph J. Vitti et al.   Annual Review of Genetics

Selection and Adaptation in the Human Genome

(2013) Wenqing Fu et al.   Annual Review of Genomics and Human Genetics

Implications of sex-specific selection for the genetic basis of disease

(2013) Edward H. Morrow et al.   Evolutionary Applications

The impact of natural selection on health and disease: uses of the population genetics approach in humans

(2013) Estelle Vasseur et al.   Evolutionary Applications

Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau

(2013) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

A General Population Genetic Framework for Antagonistic Selection That Accounts for Demography and Recurrent Mutation

(2012) T. Connallon et al.   GENETICS

Comparative studies of gene expression and the evolution of gene regulation

(2012) Irene Gallego Romero et al.   NATURE REVIEWS GENETICS

Positive Selection on the Osteoarthritis-Risk and Decreased-Height Associated Variants at the GDF5 Gene in East Asians

(2012) Dong-Dong Wu et al.   PLoS One

Constraints on the coevolution of contemporary human males and females

(2012) S. C. Stearns et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles

(2011) Ashley JR Carter et al.   BMC Medical Genetics

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Effects of BRCA1 and BRCA2 mutations on female fertility

(2011) K. R. Smith et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Birth length and weight as predictors of breast cancer prognosis

(2010) Bjørn O Mæhle et al.   BMC CANCER

Investigation on Huntington's disease in the Canadian Prairies

(2010) M. H. K. Shokeir   CLINICAL GENETICS

The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation

(2010) Jonathan K. Pritchard et al.   CURRENT BIOLOGY

The emergence of human-evolutionary medical genomics

(2010) Bernard J. Crespi   Evolutionary Applications

Survival costs of reproduction in Drosophila

(2010) Thomas Flatt   EXPERIMENTAL GERONTOLOGY

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

(2010) Kai Wang et al.   HUMAN MOLECULAR GENETICS

Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context

(2010) Alexander M. Kulminski et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Biodemography of human ageing

(2010) James W. Vaupel   NATURE

Measuring selection in contemporary human populations

(2010) Stephen C. Stearns et al.   NATURE REVIEWS GENETICS

Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E

(2010) Fotios Drenos et al.   PLoS One

Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases

(2010) Erik Corona et al.   PLoS One

Apolipoprotein E and central nervous system disorders: Reviews of clinical findings

(2010) Masatoshi Takeda et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

The CFTR Met 470 Allele Is Associated with Lower Birth Rates in Fertile Men from a Population Isolate

(2010) Gülüm Kosova et al.   PLoS Genetics

Diverse Evolutionary Histories for β-adrenoreceptor Genes in Humans

(2009) Rachele Cagliani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrating evolutionary and molecular genetics of aging

(2009) Thomas Flatt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Evolutionary Genetics of Coronary Heart Disease

(2009) Keyue Ding et al.   CIRCULATION

Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility

(2009) Taane G Clark et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genomic landscape of positive natural selection in Northern European populations

(2009) Tuuli Lappalainen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Fertility in women with BRCA mutations: a case-control study

(2009) Tuya Pal et al.   FERTILITY AND STERILITY

Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness

(2009) Axel M. Hillmer et al.   HUMAN GENETICS

The relationship between apolipoprotein E ɛ2/ɛ3/ɛ4 polymorphisms and hypertension: a meta-analysis of six studies comprising 1812 cases and 1762 controls

(2009) Wenquan Niu et al.   HYPERTENSION RESEARCH

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

(2009) H.-J. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural selection in a contemporary human population

(2009) S. G. Byars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection Control in Cystic Fibrosis: Cohorting, Cross-Contamination, and the Respiratory Therapist

(2009) Catherine A O'Malley   Respiratory Care

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

The Origins of Lactase Persistence in Europe

(2009) Yuval Itan et al.   PLoS Computational Biology

A Functional Polymorphism under Positive Evolutionary Selection in ADRB2 is Associated with Human Intelligence with Opposite Effects in the Young and the Elderly

(2008) Zoltán Bochdanovits et al.   BEHAVIOR GENETICS

The role of positive selection in determining the molecular cause of species differences in disease

(2008) Jessica J Vamathevan et al.   BMC EVOLUTIONARY BIOLOGY

Worldwide population differentiation at disease-associated SNPs

(2008) Sean Myles et al.   BMC Medical Genomics

Increased Plasma Osteoprotegerin Concentrations Are Associated with Indices of Bone Strength of the Hip

(2008) Elizabeth J. Samelson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The prevalence of cystic fibrosis in the European Union

(2008) Philip M. Farrell   Journal of Cystic Fibrosis

Gene Expression Levels Are a Target of Recent Natural Selection in the Human Genome

(2008) S. Kudaravalli et al.   MOLECULAR BIOLOGY AND EVOLUTION

Natural selection has driven population differentiation in modern humans

(2008) Luis B Barreiro et al.   NATURE GENETICS

Functional Significance of Allelic Variation at methuselah, an Aging Gene in Drosophila

(2008) Annalise B. Paaby et al.   PLoS One