Role of type I interferons in the activation of autoreactive B cells

Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN- 

(2014) M. B. Uccellini et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-  in Lupus Patients In Vivo

(2014) S. N. Kariuki et al.   JOURNAL OF IMMUNOLOGY

Evidence for Genes in Addition to Tlr7 in the Yaa Translocation Linked with Acceleration of Systemic Lupus Erythematosus

(2014) M.-L. Santiago-Raber et al.   JOURNAL OF IMMUNOLOGY

Induction of type I IFNs by intracellular DNA-sensing pathways

(2012) Taner Cavlar et al.   IMMUNOLOGY AND CELL BIOLOGY

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

(2011) Timothy B Niewold et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice

(2011) Alexis Mathian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The PYHIN protein family as mediators of host defenses

(2011) Stefan A. Schattgen et al.   IMMUNOLOGICAL REVIEWS

Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI

(2011) Amaya I. Wolf et al.   JOURNAL OF CLINICAL INVESTIGATION

Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fc  Receptor (Fc RIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein

(2011) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

Virally-Induced Upregulation of Heparan Sulfate on B Cells via the Action of Type I IFN

(2011) N. Jarousse et al.   JOURNAL OF IMMUNOLOGY

IFN-  Confers Resistance of Systemic Lupus Erythematosus Nephritis to Therapy in NZB/W F1 Mice

(2011) Z. Liu et al.   JOURNAL OF IMMUNOLOGY

Distinct Regulation of Murine Lupus Susceptibility Genes by the IRF5/Blimp-1 Axis

(2011) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

Emerging Roles for the Interferon-Inducible p200-Family Proteins in Sex Bias in Systemic Lupus Erythematosus

(2011) Divaker Choubey et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Belimumab

(2011) Iñaki Sanz et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic Targeting of B Cells for Rheumatic Autoimmune Diseases

(2011) P. Engel et al.   PHARMACOLOGICAL REVIEWS

Interferon-Alpha Triggers B Cell Effector 1 (Be1) Commitment

(2011) Marie-Ghislaine de Goër de Herve et al.   PLoS One

Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

(2011) Wibke Bayer et al.   Retrovirology

Type I interferon (IFN-α/β) rescues B-lymphocytes from apoptosis via PI3Kδ/Akt, Rho-A, NFκB and Bcl-2/BclXL

(2010) Gamal Badr et al.   CELLULAR IMMUNOLOGY

Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response

(2010) Cristina L. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus

(2010) D. A. Savitsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

(2010) Silvia N Kariuki et al.   ARTHRITIS RESEARCH & THERAPY

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Endogenous type I interferon inducers in autoimmune diseases

(2009) Doreen Finke et al.   AUTOIMMUNITY

Type I Interferons Produced by Resident Renal Cells May Promote End-Organ Disease in Autoantibody-Mediated Glomerulonephritis

(2009) A.-M. Fairhurst et al.   JOURNAL OF IMMUNOLOGY

IFN Regulatory Factor 5 Is Required for Disease Development in the Fc RIIB-/-Yaa and Fc RIIB-/- Mouse Models of Systemic Lupus Erythematosus

(2009) C. Richez et al.   JOURNAL OF IMMUNOLOGY

Marginal Zone Precursor B Cells as Cellular Agents for Type I IFN–Promoted Antigen Transport in Autoimmunity

(2009) John H. Wang et al.   JOURNAL OF IMMUNOLOGY

Murine B Cell Response to TLR7 Ligands Depends on an IFN-  Feedback Loop

(2009) N. M. Green et al.   JOURNAL OF IMMUNOLOGY

Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease

(2009) H. Agrawal et al.   JOURNAL OF IMMUNOLOGY

Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

(2009) I. Douagi et al.   JOURNAL OF IMMUNOLOGY

Interferon-β increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity

(2008) M. Krumbholz et al.   BRAIN

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral Response

(2008) Andrea Paun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

(2008) Pui Y. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BAFF is a Biological Response Marker to IFN-β Treatment in Multiple Sclerosis

(2008) Kaushal S. Gandhi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH