Article
Agriculture, Multidisciplinary
Yu Xiong, Yan-Xia Feng, Min Chang, Qian Wang, Sheng-Nan Yin, Liu-Yu Jian, Di-Feng Ren
Summary: In this study, ellagic acid (EA) and anti-inflammatory peptide (FPL) loaded chitosan nanoparticles (FPL/EA NPs) were prepared using the ionic gelation method. The synthesized nanoparticles had a spherical shape, with an average size of 308.33 +/- 4.61 nm, a high encapsulation capacity, and sustainable release of EA/FPL. The stability of the nanoparticles was evaluated and significant anti-inflammatory activity was observed.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Hyung Jun Kwon, So Young Chun, Eun Hye Lee, BoHyun Yoon, Man-Hoon Han, Jae-Wook Chung, Yun-Sok Ha, Jun Nyung Lee, Hyun Tae Kim, Dae Hwan Kim, Tae Gyun Kwon, Bum Soo Kim, Syng-Ook Lee, Byung Ik Jang
Summary: Ulcerative colitis is characterized by inflammation in the colon, and obesity is closely related to its occurrence and progression. The connection between obesity and colitis is primarily through excessive adipogenesis-related inflammatory responses that cause mucosal dysfunction. Several etiological mechanisms, including excessive adipogenesis, lipotoxicity, pro-inflammatory adipokines/cytokines, macrophage polarization, oxidative stress, endoplasmic reticulum stress, and gut microbiota, link obesity and colitis. The resulting low-grade enteric inflammations lead to mucosal layer damage, especially goblet cell dysfunction, ultimately resulting in colitis. Inhibiting the inflammatory response is the most effective approach for treating obesity-related colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yiju Li, Yuyu Zhang, Yuanrong Tuo, Haixi You, Jialu Li, Liying Wang, Xuebo Liu, Long Ding
Summary: The objective of this study was to investigate the protective effects of quinoa protein (QPro) and its derived peptides (QPep) in dextran sulfate sodium (DSS)-induced colitis in mice. The results demonstrated that QPro and QPep alleviated colitis symptoms, reduced inflammatory factor release, and improved intestinal barrier integrity through modulation of the intestinal microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Ning Cui, Cheng Yang, Xuemei Chen, Jian Zhang, Lianfu Zhang
Summary: The study aimed to compare the anti-oxidative stress and anti-inflammatory effects of all-E-lutein and its 9Z and 13Z isomers using the Caco-2 cell model. All three lutein isoforms were able to significantly reduce the secretion of IL-8 and TNF-alpha when exposed to H2O2, with 9Z-lutein and 13Z-lutein showing higher protection at lower concentrations. Furthermore, the lutein isomers up-regulated antioxidant enzymes and glutathione levels. In the anti-inflammatory assay, 9Z-lutein and all-E-lutein exhibited greater effectiveness in reducing IL-8 secretion compared to 13Z-lutein. This study provides evidence for the potential health benefits of Z-luteins.
Article
Agricultural Engineering
Lei Cai, Shengwen Wu, Chenggang Jia, Chun Cui
Summary: This study investigated the physical and chemical properties, antioxidant activity, and inhibitory mechanisms of hemp seed meal hydrolysate on alpha-glucosidase activity, as well as its effects on glucose transmembrane transport in Caco-2 cells. The hydrolysate showed reversible mixed inhibition of alpha-glucosidase and inhibited both intracellular disac-charidase and glucose transport. These findings suggest that hemp seed meal hydrolysate has potential value and application prospects in hypoglycemic effect.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Marisol Villalva, Laura Jaime, Maria de las Nieves Siles-Sanchez, Susana Santoyo
Summary: This study investigated the bioavailability of phenolic compounds in yarrow extracts using an in vitro digestion/Caco-2 model. The results showed that the phenolic composition was not affected during the oral phase, but underwent significant changes during the gastric and intestinal phases. Specifically, 3,5-DCQA degraded significantly, while luteolin-7-O-glucoside was well recovered after the intestinal step. The basolateral fraction of the Caco-2 absorption experiments contained flavonoid-aglycones, which exhibited anti-inflammatory activity by inhibiting the secretion of pro-inflammatory cytokines.
Article
Chemistry, Applied
Sonu Sharma, Ranjan Pradhan, Annamalai Manickavasagan, Apollinaire Tsopmo, Mahendra Thimmanagari, Animesh Dutta
Summary: By enzymatically hydrolyzing proteins in corn distillers solubles, a hydrolysate called AF was found to have both angiotensin-I converting enzyme (ACE) and dipeptidyl peptidase4 (DPP4) inhibition effects, with high yield and protein content. Mass spectrometry analysis revealed the presence of peptides in the AF hydrolysate, which can bind significantly with other functional groups at enzyme active sites. This demonstrates the dual bioactivity of peptides and their potential applications in food, feed, and pharmaceutical industries.
Article
Nutrition & Dietetics
Wenrong Zou, Zixin Fu, Xiaohong Guo, Lei Yao, Hui Hong, Yongkang Luo, Yuqing Tan
Summary: The study found that whey protein hydrolysate (WPH) can prevent the development of colitis, protect the colonic mucosal layer, and reduce inflammation in mice. WPH intervention also restored gut microbiome balance and increased the secretion of short-chain fatty acids. High doses of WPH had a positive impact on the microbiome, reducing harmful bacterial strains. This research suggests that WPH has anti-inflammatory properties and shows promise in managing colitis.
Article
Food Science & Technology
Juliana Santos de Espindola, Milena Ferreira Taccola, Vera Sonia Nunes da Silva, Lucilene Delazari dos Santos, Bruno Cesar Rossini, Bruna Cavecci Mendonca, Maria Teresa Bertoldo Pacheco, Fabiana Galland
Summary: During digestion in the gastrointestinal tract, whey peptides are formed and exhibit antioxidant activity, protecting the gastrointestinal cells from oxidative damage. These peptides contain hydrophobic and acidic amino acids, with lysine, valine, and tyrosine being the most abundant, which have antioxidant properties. The antioxidant activity of these peptides was found to be twice as potent as that of protein isolates at the same concentration. This study highlights the importance of whey peptides in preventing oxidative stress in the digestive system.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Wuttinont Thaweesest, Visarut Buranasudja, Rianthong Phumsuay, Chawanphat Muangnoi, Opa Vajragupta, Boonchoo Sritularak, Paitoon Rashatasakhon, Pornchai Rojsitthisak
Summary: In this study, two novel ester prodrugs of Oxyresveratrol (OXY), oxyresveratrol tetrapropionate (OXY-TPr) and oxyresveratrol tetrabutyrate (OXY-TBu), were synthesized and found to enhance the membrane permeation ability of OXY. Among them, OXY-TAc showed the most significant anti-inflammatory activity, reducing the secretion of various pro-inflammatory mediators and suppressing the activity of inflammation-related enzymes. The results suggest that OXY-TAc has improved pharmacological effects compared to its parent compound OXY.
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Bernadette Nickl, Fatimunnisa Qadri, Michael Bader
Summary: The study suggests that Gpnmb can regulate metabolic syndrome induced by obesity, reduce adipose tissue inflammation, improve insulin resistance, and liver fibrosis. Wildtype mice can develop obesity but maintain metabolic health, while Gpnmb knockout mice develop additional symptoms of metabolic syndrome along with obesity.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Wenyu Xiong, Xiaoqin Jiang, Junqiang He, Xiaoyan Liu, Yuxian Zhu, Bin Liu, Ying Huang
Summary: The study investigated the anti-aging effects of probiotic-fermented kelp enzymatic hydrolysate (KMF), supernatant (KMFS), and bacteria suspension (KMFP) in aging mice induced by D-galactose. The results showed that KMF, KMFS, and KMFP prevented the elevation of malondialdehyde levels and increased antioxidant capacity in aging mice. They also improved the cell structure of brain, liver, and intestinal tissue and influenced gut microbiota community structures.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, Research & Experimental
Riham A. El-Shiekh, Dorria Hussein, Attia H. Atta, Samar M. Mounier, Mohamed R. Mousa Shiekh, Essam Abdel-Sattar
Summary: The study highlights the potential therapeutic effects of Jasmine genus for chronic inflammatory conditions, showing anti-inflammatory and antioxidant properties. Results demonstrate that the Jasminum extract improved colon tissues in rats, reduced pro-inflammatory cytokines expression, and maintained intestinal epithelial cell junctions. The study also suggests a potential role of Jasmine in treating immune dysfunction-related chronic inflammatory disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
M. D. Martin-Arranz, L. Garcia-Ramirez, M. Hernandez-Perez, D. Montero Vega, E. Martin-Arranz, M. Sanchez-Azofra, J. Poza Cordon, J. L. Rueda Garcia, J. Noci Belda, T. Verges Martinez-Meco, P. Blanco San Miguel, C. Suarez Ferrer
Summary: Patients with inflammatory bowel disease (IBD) treated with biologic and/or immunosuppressant drugs have a higher risk of opportunistic infections. Seroprevalence studies can confirm the diagnosis of SARS-CoV-2 infections and associated risk factors. This descriptive study found that 18.64% of IBD patients tested positive for SARS-CoV-2 antibodies after one year of the pandemic, higher than the general population (15.7%). There was no significant difference in the probability of developing antibodies between patients with or without immunosuppressive treatment.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Chalamaiah Meram, Jianping Wu
FOOD RESEARCH INTERNATIONAL
(2017)
Article
Food Science & Technology
Baoguo Xu, Benxi Wei, Xiaofeng Ren, Yaogang Liu, Hao Jiang, Cunshan Zhou, Haile Ma, Meram Chalamaiah, Qiufang Liang, Zhirong Wang
FOOD AND BIOPROCESS TECHNOLOGY
(2018)
Article
Chemistry, Applied
Hui Hong, Bimol C. Roy, Meram Chalamaiah, Heather L. Bruce, Jianping Wu
Article
Chemistry, Applied
Meram Chalamaiah, Yussef Esparza, Hui Hong, Feral Temelli, Jianping Wu
Review
Chemistry, Applied
Meram Chalamaiah, Wenlin Yu, Jianping Wu
Article
Agriculture, Multidisciplinary
Qiufang Liang, Meram Chalamaiah, Xiaofeng Ren, Haile Ma, Jianping Wu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Review
Nutrition & Dietetics
Xiaofeng Wang, Myoungjin Son, Chalamaiah Meram, Jianping Wu
Article
Chemistry, Applied
Xiaofeng Ren, Ting Hou, Qiufang Liang, Xi Zhang, Di Hu, Baoguo Xu, Xinxiang Chen, Meram Chalamaiah, Haile Ma
Review
Food Science & Technology
Meram Chalamaiah, Sule Keskin Ulug, Hui Hong, Jianping Wu
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Food Science & Technology
Qiufang Liang, Meram Chalamaiah, Wang Liao, Xiaofeng Ren, Haile Ma, Jianping Wu
JOURNAL OF FUNCTIONAL FOODS
(2020)
Review
Chemistry, Applied
Hui Hong, Hongbing Fan, Meram Chalamaiah, Jianping Wu
Article
Chemistry, Medicinal
Yi Qi, Jingyi Zhou, Xiaoqin Shen, Meram Chalamaiah, Simin Lv, Hui Luo, Liang Chen
Summary: Peanut worms, unsegmented marine worms, are a good source of bioactive compounds. Studies have shown that peptides and polysaccharides derived from peanut worms have a variety of bioactive properties. However, most studies have been conducted in vitro and in animal models, and more human studies are needed for better utilization of these marine bioactive compounds.
Article
Biology
Balaji Gouda, Sukesh Narayan Sinha, Meram Chalamaiah, Validandi Vakdevi, Patangay Shashikala, Bantal Veeresh, Venkata Mullapudi Surekha, Vasudev Kasturi, Naveen Kumar Boiroju
Summary: Valproic acid (VPA) administration to 14-day postnatal (PND) BALB/c mice induces autism-like behaviors and brain histopathological changes in both males and females. Both male and female mice showed similar morphological changes in the prefrontal cortex, hippocampus and Purkinje cells. Hair loss was observed from PND 17 to 25 in both male and female mice. However, there were higher rates of change in the cerebral cortex, frontal cortex, temporal lobe and hippocampus in VPA-treated male mice. Scanning electron microscopy (SEM) showed a higher rate of phenotype changes in VPA-treated male mice in the cerebellum. Immunohistochemical analysis revealed upregulated 5-HT2A receptor protein levels in the cerebral cortex, hippocampus and Purkinje cells in VPA-treated male mice compared to control animals and VPA-treated female mice. Based on these findings, we conclude that male animals are more susceptible to VPA-induced autism spectrum disorder than females.
Article
Food Science & Technology
Cong Feng, Xinjie Song, Meram Chalamaiah, Xiaofeng Ren, Mingxing Wang, Baoguo Xu
Summary: Poor vitamin D status is a widespread issue, with a majority of dietary intake coming from fortified foods. The food industry needs to find more effective strategies for increasing vitamin D intake and improving overall health. Athletes in countries with varying levels of sunlight exposure are at risk of vitamin D deficiency, and recent advances aim to promote vitamin D utilization during sports activities.
