Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus

Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein

(2018) Jonathan W. Werner-Allen et al.   BIOCHEMISTRY

α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

(2018) Seong Su Kang et al.   EMBO JOURNAL

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

(2018) Zhi-Hao Wang et al.   Nature Communications

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease

(2017) A. J. Ehrenberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease

(2017) Seong Su Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

(2017) Sophia Schedin-Weiss et al.   Alzheimers Research & Therapy

Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus

(2017) Termpanit Chalermpalanupap et al.   NEURAL PLASTICITY

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

(2017) Sarah C. Kelly et al.   Acta Neuropathologica Communications

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases

(2016) Zhentao Zhang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)

(2015) Cristian Follmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia

(2014) E. M. Vazey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brainstem Aminergic Nuclei and Late-Life Depressive Symptoms

(2013) Robert S. Wilson et al.   JAMA Psychiatry

Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells

(2012) James M. May et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Loss of Noradrenaline Exacerbates Early Cognitive Dysfunction and Synaptic Deficits in APP/PS1 Mice

(2012) Thea Hammerschmidt et al.   BIOLOGICAL PSYCHIATRY

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

(2012) Heiko Braak et al.   CURRENT OPINION IN NEUROLOGY

Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease

(2012) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA