Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes

The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes

(2019) Deanna L. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

(2018) Michelle M. Stein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation

(2018) Youming Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide

(2017) Marina Miller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pulmonary ORMDL3 is critical for induction of Alternaria -induced allergic airways disease

(2017) Stephan Löser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeastSaccharomyces cerevisiae

(2017) Jihui Ren et al.   JOURNAL OF LIPID RESEARCH

The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21

(2016) Georg J. Loss et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase

(2016) Assem Zhakupova et al.   FASEB JOURNAL

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

(2016) Benjamin Joachim Schmiedel et al.   Nature Communications

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes

(2015) X. Li et al.   ALLERGY

Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

(2015) Clement Oyeniran et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels

(2015) Michaela Schedel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

(2014) Nathalie Acevedo et al.   HUMAN MOLECULAR GENETICS

False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies

(2014) Mark E. Glickman et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma

(2014) M. Miller et al.   JOURNAL OF IMMUNOLOGY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma

(2013) Minal Çalışkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

(2013) T. S. Worgall et al.   Science Translational Medicine

Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry

(2012) Hai H. Bui et al.   ANALYTICAL BIOCHEMISTRY

Sphingolipid Signaling in Metabolic Disorders

(2012) Timothy Hla et al.   Cell Metabolism

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

(2012) Ke Hao et al.   PLoS Genetics

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion

(2011) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease

(2009) Dominique J. Verlaan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ORMDL3Gene Is Associated with Asthma in Three Ethnically Diverse Populations

(2008) Joshua Galanter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY